TRPM6 - Transient receptor potential cation channel subfamily M member 6 - human protein (Function)
 
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TRPM6 »  Transient receptor potential cation channel subfamily M member 6   [ EC 2.7.11.1 ]
 
Protein also known as:  Melastatin-related TRP cation channel 6.
Gene name:  TRPM6
Family names: In the N-terminal section Transient receptor (TC 1.A.4) » LTrpC » TRPM6
In the C-terminal section Protein kinase » Alpha-type protein kinase » ALPK
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 61 7
GENE REF ISO

Function

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Overview 
Essential ion channel and serine/threonine-protein kinase. Crucial for magnesium homeostasis. Has an important role in epithelial magnesium transport and in the active magnesium absorption in the gut and kidney. Isoforms of the type M6-kinase lack the ion channel region.  
  • CuratedUniProtKB
According to TCDB this is a transporter from family:
the transient receptor potential ca(2+) channel (trp-cc) family  1.A.4.5.8  
GO molecular function 
ATP bindingdefinition[GO:0005524]  
  • IEAUniProtKB KW
Calcium channel activitydefinition[GO:0005262]  
  • IEAUniProtKB KW
Metal ion bindingdefinition[GO:0046872]  
  • IEAUniProtKB KW
Protein bindingdefinition[GO:0005515]  
1
  • IPIUniProtKB
Protein serine/threonine kinase activitydefinition[GO:0004674]  
  • IEAUniProtKB KW
GO biological process 
Response to toxic substancedefinition[GO:0009636]  
1
  • IDAUniProtKB
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.7.11.1: ATP + a protein ADP + a phosphoprotein.  
  • CuratedUniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathway:
Mineral absorption  hsa04978+140803  
According to Reactome, this protein belongs to the following pathway:
Transmembrane transport of small molecules  REACT_15518  
 

Keywords

Biological process 
Calcium transport  definition   [KW-0109]
Ion transport  definition   [KW-0406]
Transport  definition   [KW-0813]
Molecular function 
Calcium channel  definition   [KW-0107]
Ion channel  definition   [KW-0407]
Kinase  definition   [KW-0418]
Serine/threonine-protein kinase  definition   [KW-0723]
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: TRPM6
GenomeRNAi: 140803
PRO: PR:Q9BX84
Chemistry
GuidetoPHARMACOLOGY: 498