SGPP1 - Sphingosine-1-phosphate phosphatase 1 - human protein (Function)
 
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Gene
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SGPP1 »  Sphingosine-1-phosphate phosphatase 1   [ EC 3.1.3.- ]  (Spp1)
 
Protein also known as:  Sphingosine-1-phosphatase 1.
Gene name:  SGPP1
Entry whose protein(s) existence is based on evidence at protein level
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1 30 1
GENE REF ISO

Function

 show evidences
Overview 
Has enzymatic activity against both sphingosine 1-phosphate (S1P) and dihydro-S1P. Regulates intracellular and extracellular S1P levels.  
2
  • UniProtKB
GO molecular function 
Sphingosine-1-phosphate phosphatase activitydefinition[GO:0042392] silver  
1
  • Ortholog Compara
GO biological process 
Dephosphorylationdefinition[GO:0016311] silver  
1
  • Ortholog Compara
Extrinsic apoptotic signaling pathwaydefinition[GO:0097191] silver  
1
  • Ortholog Compara
Intrinsic apoptotic signaling pathwaydefinition[GO:0097193] silver  
1
  • Ortholog Compara
Sphinganine-1-phosphate metabolic processdefinition[GO:0006668] silver  
1
  • Ortholog Compara
Sphingosine metabolic processdefinition[GO:0006670] silver  
1
  • Ortholog Compara
Pathways 
According to KEGG, this protein belongs to the following pathway:
Sphingolipid metabolism  hsa00600+81537  
According to Reactome, this protein belongs to the following pathway:
Sphingolipid de novo biosynthesis  REACT_115810  
 

Keywords

Molecular function 
Hydrolase  definition   [KW-0378]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: SGPP1
GenomeRNAi: 81537
PRO: PR:Q9BX95