TSSK1B - Testis-specific serine/threonine-protein kinase 1 - human protein (Function)
 
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TSSK1B »  Testis-specific serine/threonine-protein kinase 1   [ EC 2.7.11.1 ]  (TSK1)
 
Protein also known as:  Serine/threonine-protein kinase 22A.
Gene name:  TSSK1B
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Testis-specific serine/threonine-protein kinase required during spermatid development. Phosphorylates 'Ser-288' of TSKS. Involved in the late stages of spermatogenesis, during the reconstruction of the cytoplasm. During spermatogenesis, required for the transformation of a ring-shaped structure around the base of the flagellum originating from the chromatoid body.  
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  • CuratedUniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524]  
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  • IDAUniProtKB
Magnesium ion bindingdefinition[GO:0000287]  
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  • IDAUniProtKB
Protein serine/threonine kinase activitydefinition[GO:0004674]  
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  • IDAUniProtKB
GO biological process 
Multicellular organismal developmentdefinition[GO:0007275]  
  • IEAUniProtKB KW
Protein phosphorylationdefinition[GO:0006468]  
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  • IDAUniProtKB
Spermatid developmentdefinition[GO:0007286]  
  • ISSOrtholog Curator
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.7.11.1: ATP + a protein ADP + a phosphoprotein.  
  • CuratedUniProtKB
It requires the following cofactor
Magnesium (By similarity).  
  • CuratedUniProtKB
It is regulated in the following manner
Kinase activity is specifically inhibited by 2 classes of compounds: biphenyl compounds (1,1'-(biphenyl-4,4'-diyl)bis(2,2-dihydroxyethanone)) and 1,2,7-trialky-1H-imidazo[4,5-g]quinoxalin-6-one. Activated by phosphorylation on Thr-174 and potentially by autophosphorylation.  
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  • CuratedUniProtKB
Note 
TSSK1B might be used as a target for male contraception or and intra-vaginal spermicides (PubMed17566264).  
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  • CuratedUniProtKB
 

Keywords

Biological process 
Differentiation  definition   [KW-0221]
Spermatogenesis  definition   [KW-0744]
Molecular function 
Developmental protein  definition   [KW-0217]
Kinase  definition   [KW-0418]
Serine/threonine-protein kinase  definition   [KW-0723]
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GenomeRNAi: 83942
PRO: PR:Q9BXA7
Chemistry
GuidetoPHARMACOLOGY: 2257