LGR4 - Leucine-rich repeat-containing G-protein coupled receptor 4 - human protein (Function)
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LGR4 »  Leucine-rich repeat-containing G-protein coupled receptor 4
Protein also known as:  G-protein coupled receptor 48.
Gene name:  LGR4
Entry whose protein(s) existence is based on evidence at protein level
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Receptor for R-spondins that potentiates the canonical Wnt signaling pathway and is involved in the formation of various organs. Upon binding to R-spondins (RSPO1, RSPO2, RSPO3 or RSPO4), associates with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. In contrast to classical G-protein coupled receptors, does not activate heterotrimeric G-proteins to transduce the signal. Its function as activator of the Wnt signaling pathway is required for the development of various organs, including liver, kidney, intestine, bone, reproductive tract and eye. May also act as a receptor for norrin (NDP), such results however require additional confirmation in vivo. Required during spermatogenesis to activate the Wnt signaling pathway in peritubular myoid cells. Required for the maintenance of intestinal stem cells and Paneth cell differentiation in postnatal intestinal crypts. Acts as a regulator of bone formation and remodeling. Involved in kidney development; required for maintaining the ureteric bud in an undifferentiated state. Involved in the development of the anterior segment of the eye. Required during erythropoiesis. Also acts as a negative regulator of innate immunity by inhibiting TLR2/TLR4 associated pattern-recognition and proinflammatory cytokine production.  
  • CuratedUniProtKB
GO molecular function 
Not  G-protein coupled receptor activitydefinition[GO:0004930]  
  • IDAUniProtKB
Protein bindingdefinition[GO:0005515]  
  • IPIUniProtKB
Transmembrane signaling receptor activitydefinition[GO:0004888]  
  • IDAUniProtKB
GO biological process 
Bone mineralizationdefinition[GO:0030282]  
  • ISSOrtholog Curator
Bone remodelingdefinition[GO:0046849]  
  • ISSOrtholog Curator
Canonical Wnt signaling pathway involved in metanephric kidney developmentdefinition[GO:0061290] silver  
  • IEAOrtholog Compara
Cell differentiation involved in metanephros developmentdefinition[GO:0072202] silver  
  • IEAOrtholog Compara
Epithelial cell proliferationdefinition[GO:0050673] silver  
  • IEAOrtholog Compara
G-protein coupled receptor signaling pathwaydefinition[GO:0007186]  
  • IEAUniProtKB KW
Innate immune responsedefinition[GO:0045087]  
  • IEAUniProtKB KW
Male genitalia developmentdefinition[GO:0030539] silver  
  • IEAOrtholog Compara
Metanephric glomerulus developmentdefinition[GO:0072224] silver  
  • IEAOrtholog Compara
Metanephric nephron tubule morphogenesisdefinition[GO:0072282] silver  
  • IEAOrtholog Compara
Negative regulation of cytokine secretiondefinition[GO:0050710]  
  • ISSOrtholog Curator
Negative regulation of toll-like receptor signaling pathwaydefinition[GO:0034122]  
  • ISSOrtholog Curator
Negative regulation of transcription, DNA-templateddefinition[GO:0045892] silver  
  • IEAOrtholog Compara
Osteoblast differentiationdefinition[GO:0001649]  
  • ISSOrtholog Curator
Positive regulation of branching involved in ureteric bud morphogenesisdefinition[GO:0090190] silver  
  • IEAOrtholog Compara
Positive regulation of canonical Wnt signaling pathwaydefinition[GO:0090263]  
  • IDAUniProtKB
Positive regulation of transcription, DNA-templateddefinition[GO:0045893] silver  
  • IEAOrtholog Compara
  • ISSOrtholog Curator
According to Reactome, this protein belongs to the following pathway:
regulation of FZD by ubiquitination  REACT_200716  


Biological process 
Differentiation  definition   [KW-0221]
Immunity  definition   [KW-0391]
Innate immunity  definition   [KW-0399]
Spermatogenesis  definition   [KW-0744]
Wnt signaling pathway  definition   [KW-0879]
Molecular function 
Developmental protein  definition   [KW-0217]
G-protein coupled receptor  definition   [KW-0297]
Receptor  definition   [KW-0675]
Transducer  definition   [KW-0807]
Technical term 
Reference proteome  definition   [KW-1185]

Further external links

GeneWiki: LGR4
GenomeRNAi: 55366