LGR4 - Leucine-rich repeat-containing G-protein coupled receptor 4 - human protein (Function)
 
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LGR4 »  Leucine-rich repeat-containing G-protein coupled receptor 4
 
Protein also known as:  G-protein coupled receptor 48.
Gene name:  LGR4
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 34 2
GENE REF ISO

Function

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Overview 
Receptor for R-spondins that potentiates the canonical Wnt signaling pathway and is involved in the formation of various organs. Upon binding to R-spondins (RSPO1, RSPO2, RSPO3 or RSPO4), associates with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. In contrast to classical G-protein coupled receptors, does not activate heterotrimeric G-proteins to transduce the signal. Its function as activator of the Wnt signaling pathway is required for the development of various organs, including liver, kidney, intestine, bone, reproductive tract and eye. May also act as a receptor for norrin (NDP), such results however require additional confirmation in vivo. Required during spermatogenesis to activate the Wnt signaling pathway in peritubular myoid cells. Required for the maintenance of intestinal stem cells and Paneth cell differentiation in postnatal intestinal crypts. Acts as a regulator of bone formation and remodeling. Involved in kidney development; required for maintaining the ureteric bud in an undifferentiated state. Involved in the development of the anterior segment of the eye. Required during erythropoiesis. Also acts as a negative regulator of innate immunity by inhibiting TLR2/TLR4 associated pattern-recognition and proinflammatory cytokine production. Plays an important role in regulating the circadian rhythms of plasma lipids, partially through regulating the rhythmic expression of MTTP (By similarity).  
8
  • UniProtKB
GO molecular function 
Not  G-protein coupled receptor activitydefinition[GO:0004930]  
1
  • UniProtKB
Protein bindingdefinition[GO:0005515]  
2
  • UniProtKB
Transmembrane signaling receptor activitydefinition[GO:0004888]  
2
  • UniProtKB
GO biological process 
Bone mineralizationdefinition[GO:0030282]  
1
  • Ortholog Curator
Bone remodelingdefinition[GO:0046849]  
1
  • Ortholog Curator
Canonical Wnt signaling pathway involved in metanephric kidney developmentdefinition[GO:0061290] silver  
1
  • Ortholog Compara
Cell differentiation involved in metanephros developmentdefinition[GO:0072202] silver  
1
  • Ortholog Compara
Circadian regulation of gene expressiondefinition[GO:0032922]  
1
  • Ortholog Curator
Epithelial cell proliferationdefinition[GO:0050673] silver  
1
  • Ortholog Compara
G-protein coupled receptor signaling pathwaydefinition[GO:0007186]  
1
  • UniProtKB KW
Innate immune responsedefinition[GO:0045087]  
1
  • UniProtKB KW
Male genitalia developmentdefinition[GO:0030539] silver  
1
  • Ortholog Compara
Metanephric glomerulus developmentdefinition[GO:0072224] silver  
1
  • Ortholog Compara
Metanephric nephron tubule morphogenesisdefinition[GO:0072282] silver  
1
  • Ortholog Compara
Negative regulation of cytokine secretiondefinition[GO:0050710]  
1
  • Ortholog Curator
Negative regulation of toll-like receptor signaling pathwaydefinition[GO:0034122]  
1
  • Ortholog Curator
Negative regulation of transcription, DNA-templateddefinition[GO:0045892] silver  
1
  • Ortholog Compara
Osteoblast differentiationdefinition[GO:0001649]  
1
  • Ortholog Curator
Positive regulation of branching involved in ureteric bud morphogenesisdefinition[GO:0090190] silver  
1
  • Ortholog Compara
Positive regulation of canonical Wnt signaling pathwaydefinition[GO:0090263]  
1
  • UniProtKB
Positive regulation of transcription, DNA-templateddefinition[GO:0045893] silver  
1
  • Ortholog Compara
Spermatogenesisdefinition[GO:0007283]  
1
  • Ortholog Curator
Pathways 
According to Reactome, this protein belongs to the following pathway:
regulation of FZD by ubiquitination  REACT_200716  
 

Keywords

Biological process 
Biological rhythms  definition   [KW-0090]
Differentiation  definition   [KW-0221]
Immunity  definition   [KW-0391]
Innate immunity  definition   [KW-0399]
Spermatogenesis  definition   [KW-0744]
Wnt signaling pathway  definition   [KW-0879]
Molecular function 
Developmental protein  definition   [KW-0217]
G-protein coupled receptor  definition   [KW-0297]
Receptor  definition   [KW-0675]
Transducer  definition   [KW-0807]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: LGR4
GenomeRNAi: 55366
PRO: PR:Q9BXB1
Chemistry
GuidetoPHARMACOLOGY: 147