NPL - N-acetylneuraminate lyase - human protein (Function)
 
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Protein
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References

 
NPL »  N-acetylneuraminate lyase   [ EC 4.1.3.3 ]  (NALase)
 
Protein also known as:  N-acetylneuraminate pyruvate-lyase.
Gene name:  NPL
Family name: DapA » NanA
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Catalyzes the cleavage of N-acetylneuraminic acid (sialic acid) to form pyruvate and N-acetylmannosamine via a Schiff base intermediate. It prevents sialic acids from being recycled and returning to the cell surface. Involved in the N-glycolylneuraminic acid (Neu5Gc) degradation pathway. Although human is not able to catalyze formation of Neu5Gc due to the inactive CMAHP enzyme, Neu5Gc is present in food and must be degraded (By similarity).  
  • CuratedUniProtKB
GO molecular function 
N-acetylneuraminate lyase activitydefinition[GO:0008747]  
  • ISSOrtholog Curator
GO biological process 
Carbohydrate metabolic processdefinition[GO:0005975]  
  • IEAUniProtKB KW
N-acetylneuraminate catabolic processdefinition[GO:0019262]  
1
  • TASUniProtKB
  • IEAUniPathway
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 4.1.3.3: N-acetylneuraminate N-acetyl-D-mannosamine + pyruvate.  
  • CuratedUniProtKB
Pathways 
This protein is involved in the following pathway
According to KEGG, this protein belongs to the following pathway:
Amino sugar and nucleotide sugar metabolism  hsa00520+80896  
According to Reactome, this protein belongs to the following pathway:
Metabolism of proteins  REACT_17015  
 

Keywords

Biological process 
Carbohydrate metabolism  definition   [KW-0119]
Molecular function 
Lyase  definition   [KW-0456]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 80896
PRO: PR:Q9BXD5