NPL - N-acetylneuraminate lyase - human protein (Function)
 
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NPL »  N-acetylneuraminate lyase   [ EC 4.1.3.3 ]  (NALase)
 
Protein also known as:  N-acetylneuraminate pyruvate-lyase.
Gene name:  NPL
Family name: DapA » NanA
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Catalyzes the cleavage of N-acetylneuraminic acid (sialic acid) to form pyruvate and N-acetylmannosamine via a Schiff base intermediate. It prevents sialic acids from being recycled and returning to the cell surface. Involved in the N-glycolylneuraminic acid (Neu5Gc) degradation pathway. Although human is not able to catalyze formation of Neu5Gc due to the inactive CMAHP enzyme, Neu5Gc is present in food and must be degraded (By similarity).  
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  • UniProtKB
GO molecular function 
N-acetylneuraminate lyase activitydefinition[GO:0008747]  
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  • Ortholog Curator
Protein bindingdefinition[GO:0005515]  
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  • IntAct
GO biological process 
N-acetylneuraminate catabolic processdefinition[GO:0019262]  
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  • UniProtKB
  • UniPathway
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 4.1.3.3: N-acetylneuraminate N-acetyl-D-mannosamine + pyruvate.  
1
  • UniProtKB
 
More information is available from:
Pathways 
This protein is involved in the following pathway
Amino-sugar metabolism; N-acetylneuraminate degradation  
2
  • UniProtKB
According to KEGG, this protein belongs to the following pathway:
Amino sugar and nucleotide sugar metabolism  hsa00520+80896  
According to Reactome, this protein belongs to the following pathway:
Sialic acid metabolism  REACT_264366  
 

Keywords

Biological process 
Carbohydrate metabolism  definition   [KW-0119]
Molecular function 
Lyase  definition   [KW-0456]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 80896
PRO: PR:Q9BXD5