CARD14 - Caspase recruitment domain-containing protein 14 - human protein (Function)
 
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CARD14 »  Caspase recruitment domain-containing protein 14
 
Protein also known as:  CARD-containing MAGUK protein 2 (Carma 2).
Gene name:  CARD14
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Plays a role in signaling mediated by TRAF2, TRAF3 and TRAF6 and protects cells against apoptosis. Activates NF-kappa-B via BCL10 and IKK. Stimulates the phosphorylation of BCL10.  
1
  • CuratedUniProtKB
GO molecular function 
CARD domain bindingdefinition[GO:0050700]  
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  • IPIUniProtKB
GO biological process 
Activation of NF-kappaB-inducing kinase activitydefinition[GO:0007250]  
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  • NASUniProtKB
Apoptotic processdefinition[GO:0006915]  
  • IEAUniProtKB KW
Negative regulation of apoptotic processdefinition[GO:0043066]  
1
  • IMPUniProtKB
Positive regulation of NF-kappaB transcription factor activitydefinition[GO:0051092]  
1
  • IMPUniProtKB
Positive regulation of protein phosphorylationdefinition[GO:0001934]  
1
  • IDAUniProtKB
Tumor necrosis factor-mediated signaling pathwaydefinition[GO:0033209]  
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  • IMPUniProtKB
Caution 
Supposed to contain a SH3 domain which is not detected by PROSITE, Pfam or SMART.  
  • CuratedUniProtKB
 

Keywords

Biological process 
Apoptosis  definition   [KW-0053]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: CARD14
GenomeRNAi: 79092
PRO: PR:Q9BXL6