CARD11 - Caspase recruitment domain-containing protein 11 - human protein (Function)
 
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CARD11 »  Caspase recruitment domain-containing protein 11
 
Protein also known as:  CARD-containing MAGUK protein 1 (Carma 1).
Gene name:  CARD11
Entry whose protein(s) existence is based on evidence at protein level
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1 82 1
GENE REF ISO

Function

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Overview 
Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Activates NF-kappa-B via BCL10 and IKK. Stimulates the phosphorylation of BCL10.  
  • CuratedUniProtKB
GO molecular function 
CARD domain bindingdefinition[GO:0050700]  
1
  • IPIUniProtKB
Guanylate kinase activitydefinition[GO:0004385]  
1
  • NASUniProtKB
Protein bindingdefinition[GO:0005515]  
5
  • IPIIntAct
  • IPIUniProtKB
GO biological process 
Nucleotide phosphorylationdefinition[GO:0046939]  
1
  • NASGOC
Positive regulation of B cell proliferationdefinition[GO:0030890] silver  
  • IEAOrtholog Compara
Positive regulation of cytokine productiondefinition[GO:0001819]  
1
  • IMPUniProtKB
Positive regulation of I-kappaB kinase/NF-kappaB signalingdefinition[GO:0043123] silver  
  • IEAOrtholog Compara
Positive regulation of interleukin-2 biosynthetic processdefinition[GO:0045086] silver  
  • IEAOrtholog Compara
Positive regulation of NF-kappaB transcription factor activitydefinition[GO:0051092]  
1
  • IMPUniProtKB
Positive regulation of T cell proliferationdefinition[GO:0042102] silver  
  • IEAOrtholog Compara
Regulation of apoptotic processdefinition[GO:0042981] silver  
  • IEAInterPro 2 GO
Regulation of B cell differentiationdefinition[GO:0045577] silver  
  • IEAOrtholog Compara
Regulation of T cell differentiationdefinition[GO:0045580] silver  
  • IEAOrtholog Compara
T cell costimulationdefinition[GO:0031295]  
1
  • IDAUniProtKB
Thymic T cell selectiondefinition[GO:0045061] silver  
  • IEAOrtholog Compara
Pathways 
According to KEGG, this protein belongs to the following pathways:
B cell receptor signaling pathway  hsa04662+84433  
T cell receptor signaling pathway  hsa04660+84433  
According to Reactome, this protein belongs to the following pathways:
Activation of NF-kappaB in B cells  REACT_118656  
Downstream TCR signaling  REACT_12555  
FCERI mediated NF-kB activation  REACT_163994  
Caution 
Supposed to contain a SH3 domain which is not detected by PROSITE, Pfam or SMART.  
  • CuratedUniProtKB
 

Keywords

Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: CARD11
GenomeRNAi: 84433
PRO: PR:Q9BXL7