PINK1 - Serine/threonine-protein kinase PINK1, mitochondrial - human protein (Function)
 
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PINK1 »  Serine/threonine-protein kinase PINK1, mitochondrial   [ EC 2.7.11.1 ]
 
Protein also known as:  PTEN-induced putative kinase protein 1.
Gene name:  PINK1
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 195 2
GENE REF ISO

Function

 show evidences
Overview 
Protects against mitochondrial dysfunction during cellular stress by phosphorylating mitochondrial proteins. Involved in the clearance of damaged mitochondria via selective autophagy (mitophagy) by mediating activation and translocation of PARK2. Targets PARK2 to dysfunctional depolarized mitochondria through the phosphorylation of MFN2. Activates PARK2 in 2 steps: (1) by mediating phosphorylation at 'Ser-65' of PARK2 and (2) mediating phosphorylation of ubiquitin, converting PARK2 to its fully-active form (PubMed24660806, PubMed24751536, PubMed24784582).  
13
  • UniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524]  
1
  • UniProtKB
C3HC4-type RING finger domain bindingdefinition[GO:0055131]  
1
  • BHF-UCL
Calcium-dependent protein kinase activitydefinition[GO:0010857]  
1
  • BHF-UCL
Kinase activitydefinition[GO:0016301]  
2
  • ParkinsonsUK-UCL
  • MGI
Magnesium ion bindingdefinition[GO:0000287]  
1
  • UniProtKB
Peptidase activator activitydefinition[GO:0016504]  
1
  • ParkinsonsUK-UCL
Protease bindingdefinition[GO:0002020]  
2
  • ParkinsonsUK-UCL
Protein bindingdefinition[GO:0005515]  
9
  • ParkinsonsUK-UCL
  • IntAct
Protein kinase B bindingdefinition[GO:0043422]  
1
  • ParkinsonsUK-UCL
Protein serine/threonine kinase activitydefinition[GO:0004674]  
5
  • UniProtKB
  • ParkinsonsUK-UCL
  • BHF-UCL
Ubiquitin protein ligase bindingdefinition[GO:0031625]  
1
  • UniProtKB
GO biological process 
Activation of protein kinase B activitydefinition[GO:0032148]  
1
  • ParkinsonsUK-UCL
Cellular response to hypoxiadefinition[GO:0071456]  
1
  • ParkinsonsUK-UCL
Cellular response to toxic substancedefinition[GO:0097237]  
1
  • ParkinsonsUK-UCL
Intracellular signal transductiondefinition[GO:0035556]  
1
  • UniProtKB
Mitochondrion degradationdefinition[GO:0000422]  
3
  • UniProtKB
Mitochondrion organizationdefinition[GO:0007005]  
1
  • ParkinsonsUK-UCL
Negative regulation of gene expressiondefinition[GO:0010629]  
1
  • ParkinsonsUK-UCL
Negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathwaydefinition[GO:1903384]  
2
  • ParkinsonsUK-UCL
Negative regulation of JNK cascadedefinition[GO:0046329]  
1
  • ParkinsonsUK-UCL
Negative regulation of neuron apoptotic processdefinition[GO:0043524]  
1
  • ParkinsonsUK-UCL
Negative regulation of oxidative stress-induced cell deathdefinition[GO:1903202]  
1
  • ParkinsonsUK-UCL
Negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathwaydefinition[GO:1902176]  
1
  • ParkinsonsUK-UCL
Negative regulation of oxidative stress-induced neuron deathdefinition[GO:1903204]  
1
  • ParkinsonsUK-UCL
Negative regulation of reactive oxygen species metabolic processdefinition[GO:2000378]  
1
  • ParkinsonsUK-UCL
Peptidyl-serine autophosphorylationdefinition[GO:0036289]  
1
  • ParkinsonsUK-UCL
Peptidyl-serine phosphorylationdefinition[GO:0018105]  
3
  • ParkinsonsUK-UCL
  • BHF-UCL
Phosphorylationdefinition[GO:0016310]  
1
  • ParkinsonsUK-UCL
Positive regulation of dopamine secretiondefinition[GO:0033603] silver  
1
  • Ortholog Compara
Positive regulation of I-kappaB kinase/NF-kappaB signalingdefinition[GO:0043123]  
1
  • BHF-UCL
Positive regulation of mitochondrial electron transport, NADH to ubiquinonedefinition[GO:1902958]  
1
  • ParkinsonsUK-UCL
Positive regulation of mitochondrial fissiondefinition[GO:0090141]  
1
  • RefGenome
Positive regulation of peptidase activitydefinition[GO:0010952]  
1
  • ParkinsonsUK-UCL
Positive regulation of peptidyl-serine phosphorylationdefinition[GO:0033138]  
2
  • ParkinsonsUK-UCL
Positive regulation of protein kinase B signalingdefinition[GO:0051897]  
1
  • ParkinsonsUK-UCL
Positive regulation of release of cytochrome c from mitochondriadefinition[GO:0090200]  
1
  • BHF-UCL
Positive regulation of synaptic transmission, dopaminergicdefinition[GO:0032226] silver  
1
  • Ortholog Compara
Positive regulation of ubiquitin-protein transferase activitydefinition[GO:0051443]  
1
  • ParkinsonsUK-UCL
Protein phosphorylationdefinition[GO:0006468]  
3
  • ParkinsonsUK-UCL
  • UniProtKB
Protein ubiquitinationdefinition[GO:0016567]  
1
  • UniProtKB
Regulation of mitochondrial membrane potentialdefinition[GO:0051881]  
3
  • ParkinsonsUK-UCL
Regulation of mitochondrion degradationdefinition[GO:1903146]  
1
  • ParkinsonsUK-UCL
Regulation of protein complex assemblydefinition[GO:0043254]  
1
  • BHF-UCL
Regulation of protein ubiquitinationdefinition[GO:0031396]  
1
  • BHF-UCL
Regulation of reactive oxygen species metabolic processdefinition[GO:2000377]  
2
  • ParkinsonsUK-UCL
Regulation of synaptic vesicle transportdefinition[GO:1902803]  
1
  • ParkinsonsUK-UCL
Response to oxidative stressdefinition[GO:0006979]  
1
  • ParkinsonsUK-UCL
Response to stressdefinition[GO:0006950]  
1
  • UniProtKB
TORC2 signalingdefinition[GO:0038203]  
1
  • ParkinsonsUK-UCL
Ubiquitin-dependent protein catabolic processdefinition[GO:0006511]  
1
  • ParkinsonsUK-UCL
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.7.11.1: ATP + a protein ADP + a phosphoprotein.  
4
  • UniProtKB
It requires the following cofactor
 Mg(2+)  
1
  • UniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathway:
Parkinson's disease  hsa05012+65018  
 

Keywords

Biological process 
Autophagy  definition   [KW-0072]
Molecular function 
Kinase  definition   [KW-0418]
Serine/threonine-protein kinase  definition   [KW-0723]
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: PINK1
GenomeRNAi: 65018
PRO: PR:Q9BXM7