PINK1 - Serine/threonine-protein kinase PINK1, mitochondrial - human protein (Function)
 
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PINK1 »  Serine/threonine-protein kinase PINK1, mitochondrial
 
Gene name:  PINK1
Entry whose protein(s) existence is based on evidence at protein level
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1 183 2
GENE REF ISO

Function

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Overview 
Protects against mitochondrial dysfunction during cellular stress by phosphorylating mitochondrial proteins. Involved in the clearance of damaged mitochondria via selective autophagy (mitophagy) by mediating activation and translocation of PARK2. Targets PARK2 to dysfunctional depolarized mitochondria through the phosphorylation of MFN2. Activates PARK2 in 2 steps: (1) by mediating phosphorylation at 'Ser-65' of PARK2 and (2) mediating phosphorylation of ubiquitin, converting PARK2 to its fully-active form.  
7
  • CuratedUniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524]  
1
  • IDAUniProtKB
C3HC4-type RING finger domain bindingdefinition[GO:0055131]  
1
  • IPIBHF-UCL
Calcium-dependent protein kinase activitydefinition[GO:0010857]  
1
  • IDABHF-UCL
Kinase activitydefinition[GO:0016301]  
1
  • IDAMGI
Magnesium ion bindingdefinition[GO:0000287]  
1
  • IDAUniProtKB
Protein bindingdefinition[GO:0005515]  
6
  • IPIIntAct
  • IPIParkinsonsUK-UCL
Protein serine/threonine kinase activitydefinition[GO:0004674]  
4
  • IDAUniProtKB
  • IDABHF-UCL
  • IDAParkinsonsUK-UCL
Ubiquitin protein ligase bindingdefinition[GO:0031625]  
1
  • IPIUniProtKB
GO biological process 
Cell deathdefinition[GO:0008219]  
  • IEAUniProtKB KW
Cellular response to toxic substancedefinition[GO:0097237] silver  
  • IEAOrtholog Compara
Intracellular signal transductiondefinition[GO:0035556]  
1
  • IDAUniProtKB
Mitochondrion degradationdefinition[GO:0000422]  
3
  • IMPUniProtKB
Negative regulation of neuron apoptotic processdefinition[GO:0043524] silver  
  • IEAOrtholog Compara
Negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathwaydefinition[GO:1902176]  
1
  • IDAParkinsonsUK-UCL
Peptidyl-serine phosphorylationdefinition[GO:0018105]  
2
  • IDABHF-UCL
  • IDAParkinsonsUK-UCL
Positive regulation of dopamine secretiondefinition[GO:0033603] silver  
  • IEAOrtholog Compara
Positive regulation of I-kappaB kinase/NF-kappaB signalingdefinition[GO:0043123]  
1
  • IDABHF-UCL
Positive regulation of release of cytochrome c from mitochondriadefinition[GO:0090200]  
1
  • IMPBHF-UCL
Positive regulation of synaptic transmission, dopaminergicdefinition[GO:0032226] silver  
  • IEAOrtholog Compara
Protein phosphorylationdefinition[GO:0006468]  
1
  • IDAUniProtKB
Protein ubiquitinationdefinition[GO:0016567]  
1
  • IMPUniProtKB
Regulation of protein complex assemblydefinition[GO:0043254]  
1
  • IDABHF-UCL
Regulation of protein ubiquitinationdefinition[GO:0031396]  
1
  • IDABHF-UCL
Response to stressdefinition[GO:0006950]  
1
  • IDAUniProtKB
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.7.11.1: ATP + a protein ADP + a phosphoprotein.  
  • CuratedUniProtKB
It requires the following cofactor
Magnesium.  
1
  • CuratedUniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathway:
Parkinson's disease  hsa05012+65018  
 

Keywords

Biological process 
Autophagy  definition   [KW-0072]
Molecular function 
Kinase  definition   [KW-0418]
Serine/threonine-protein kinase  definition   [KW-0723]
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: PINK1
GenomeRNAi: 65018
PRO: PR:Q9BXM7