PINK1 - Serine/threonine-protein kinase PINK1, mitochondrial - human protein (Medical)
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PINK1 »  Serine/threonine-protein kinase PINK1, mitochondrial   [ EC ]
Protein also known as:  PTEN-induced putative kinase protein 1.
Gene name:  PINK1
Entry whose protein(s) existence is based on evidence at protein level
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1 173 2

Displayed isoform: Iso 1     



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Parkinson disease 6 (PARK6) [MIM:605909]: A neurodegenerative disorder characterized by parkinsonian signs such as rigidity, resting tremor and bradykinesia. A subset of patients manifest additional symptoms including hyperreflexia, autonomic instability, dementia and psychiatric disturbances. Symptoms show diurnal fluctuation and can improve after sleep. The disease is caused by mutations affecting the gene represented in this entry.  
  • CuratedUniProtKB
According to Orphanet, this protein is involved in the following disease:
Young adult-onset Parkinsonism  2828  


Disease mutation  definition   [KW-0225]
Neurodegeneration  definition   [KW-0523]
Parkinson disease  definition   [KW-0907]
Parkinsonism  definition   [KW-0908]
Technical term 
Reference proteome  definition   [KW-1185]

Further external links

Organism-specific databases
CTD: 65018
MIM: 605909
MIM: 168600
PharmGKB: PA33325
Polymorphism databases
DMDM: 48428484
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.