ASPN - Asporin - human protein (Function)
 
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Protein
Gene
References

 
ASPN »  Asporin
 
Protein also known as:  Periodontal ligament-associated protein 1 (PLAP-1).
Gene name:  ASPN
Entry whose protein(s) existence is based on evidence at protein level
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1 32 1
GENE REF ISO

Function

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Overview 
Negatively regulates periodontal ligament (PDL) differentiation and mineralization to ensure that the PDL is not ossified and to maintain homeostasis of the tooth-supporting system. Inhibits BMP2-induced cytodifferentiation of PDL cells by preventing its binding to BMPR1B/BMP type-1B receptor, resulting in inhibition of BMP-dependent activation of SMAD proteins (By similarity). Critical regulator of TGF-beta in articular cartilage and plays an essential role in cartilage homeostasis and osteoarthritis (OA) pathogenesis. Negatively regulates chondrogenesis in the articular cartilage by blocking the TGF-beta/receptor interaction on the cell surface and inhibiting the canonical TGF-beta/Smad signal. Binds calcium and plays a role in osteoblast-driven collagen biomineralization activity.  
2
  • CuratedUniProtKB
GO molecular function 
Calcium ion bindingdefinition[GO:0005509]  
1
  • IDAUniProtKB
Collagen bindingdefinition[GO:0005518] silver  
  • IEAInterPro 2 GO
GO biological process 
Bone mineralizationdefinition[GO:0030282]  
1
  • IDAUniProtKB
Negative regulation of tooth mineralizationdefinition[GO:0070171]  
  • ISSOrtholog Curator
Negative regulation of transforming growth factor beta receptor signaling pathwaydefinition[GO:0030512]  
1
  • IDAUniProtKB
Pathways 
According to Reactome, this protein belongs to the following pathway:
Extracellular matrix organization  REACT_118779  
 

Keywords

Biological process 
Biomineralization  definition   [KW-0091]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: Asporin
GenomeRNAi: 54829
PRO: PR:Q9BXN1