CLEC7A - C-type lectin domain family 7 member A - human protein (Function)
 
Home Recent activites arrow-down favorite My favorites arrow-down favorite My labels arrow-down Downloads
Back to ...  
Publication View
Protein
Gene
References

 
CLEC7A »  C-type lectin domain family 7 member A
 
Protein also known as:  Dendritic cell-associated C-type lectin 1 (Dectin-1).
Gene name:  CLEC7A
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 29 10
GENE REF ISO

Function

 show evidences
Overview 
Lectin that functions as pattern receptor specific for beta-1,3-linked and beta-1,6-linked glucans, such as cell wall constituents from pathogenic bacteria and fungi. Necessary for the TLR2-mediated inflammatory response and for TLR2-mediated activation of NF-kappa-B. Enhances cytokine production in macrophages and dendritic cells. Mediates production of reactive oxygen species in the cell. Mediates phagocytosis of C.albicans conidia. Binds T-cells in a way that does not involve their surface glycans and plays a role in T-cell activation. Stimulates T-cell proliferation (By similarity).  
3
  • CuratedUniProtKB
GO molecular function 
(1->3)-beta-D-glucan bindingdefinition[GO:0001872] silver  
  • IEAOrtholog Compara
(1->3)-beta-D-glucan receptor activitydefinition[GO:0001874] silver  
  • IEAOrtholog Compara
Carbohydrate bindingdefinition[GO:0030246]  
1
  • IDAUniProtKB
Metal ion bindingdefinition[GO:0046872]  
  • IEAUniProtKB KW
MHC protein bindingdefinition[GO:0042287]  
1
  • NASUniProtKB
Opsonin bindingdefinition[GO:0001846] silver  
  • IEAOrtholog Compara
Signaling pattern recognition receptor activitydefinition[GO:0008329]  
1
  • IDAUniProtKB
GO biological process 
Carbohydrate mediated signalingdefinition[GO:0009756]  
1
  • TASUniProtKB
Cell recognitiondefinition[GO:0008037]  
1
  • IDAUniProtKB
Cell surface pattern recognition receptor signaling pathwaydefinition[GO:0002752] silver  
  • IEAOrtholog Compara
Cellular response to molecule of fungal origindefinition[GO:0071226] silver  
  • IEAOrtholog Compara
Defense response to protozoandefinition[GO:0042832]  
1
  • NASUniProtKB
Detection of yeastdefinition[GO:0001879] silver  
  • IEAOrtholog Compara
Inflammatory responsedefinition[GO:0006954]  
  • IEAUniProtKB KW
Innate immune responsedefinition[GO:0045087] silver  
  • IEAOrtholog Compara
Leukocyte activation involved in immune responsedefinition[GO:0002366] silver  
  • IEAOrtholog Compara
Phagocytosis, engulfmentdefinition[GO:0006911] silver  
  • IEAOrtholog Compara
Phagocytosis, recognitiondefinition[GO:0006910]  
1
  • IDAUniProtKB
Positive regulation of phagocytosisdefinition[GO:0050766] silver  
  • IEAOrtholog Compara
Positive regulation of tumor necrosis factor productiondefinition[GO:0032760] silver  
  • IEAOrtholog Compara
Single organismal cell-cell adhesiondefinition[GO:0016337] silver  
  • IEAOrtholog Compara
T cell activationdefinition[GO:0042110]  
1
  • TASUniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathways:
Phagosome  hsa04145+64581  
Tuberculosis  hsa05152+64581  
 

Keywords

Biological process 
Immunity  definition   [KW-0391]
Inflammatory response  definition   [KW-0395]
Innate immunity  definition   [KW-0399]
Molecular function 
Receptor  definition   [KW-0675]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: CLEC7A
GenomeRNAi: 64581
PRO: PR:Q9BXN2