CLEC7A - C-type lectin domain family 7 member A - human protein (Function)
 
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CLEC7A »  C-type lectin domain family 7 member A
 
Protein also known as:  Dendritic cell-associated C-type lectin 1 (Dectin-1).
Gene name:  CLEC7A
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Lectin that functions as pattern receptor specific for beta-1,3-linked and beta-1,6-linked glucans, such as cell wall constituents from pathogenic bacteria and fungi. Necessary for the TLR2-mediated inflammatory response and for TLR2-mediated activation of NF-kappa-B. Enhances cytokine production in macrophages and dendritic cells. Mediates production of reactive oxygen species in the cell. Mediates phagocytosis of C.albicans conidia. Binds T-cells in a way that does not involve their surface glycans and plays a role in T-cell activation. Stimulates T-cell proliferation (By similarity).  
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  • UniProtKB
GO molecular function 
Carbohydrate bindingdefinition[GO:0030246]  
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  • UniProtKB
Metal ion bindingdefinition[GO:0046872]  
1
  • UniProtKB KW
MHC protein bindingdefinition[GO:0042287]  
1
  • UniProtKB
Signaling pattern recognition receptor activitydefinition[GO:0008329]  
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  • UniProtKB
GO biological process 
Carbohydrate mediated signalingdefinition[GO:0009756]  
1
  • UniProtKB
Cell recognitiondefinition[GO:0008037]  
1
  • UniProtKB
Defense response to protozoandefinition[GO:0042832]  
1
  • UniProtKB
Inflammatory responsedefinition[GO:0006954]  
1
  • UniProtKB KW
Innate immune responsedefinition[GO:0045087]  
1
  • UniProtKB KW
Pattern recognition receptor signaling pathwaydefinition[GO:0002221]  
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  • GOC
Phagocytosis, recognitiondefinition[GO:0006910]  
1
  • UniProtKB
T cell activationdefinition[GO:0042110]  
1
  • UniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathways:
Phagosome  hsa04145+64581  
Tuberculosis  hsa05152+64581  
 

Keywords

Biological process 
Immunity  definition   [KW-0391]
Inflammatory response  definition   [KW-0395]
Innate immunity  definition   [KW-0399]
Molecular function 
Receptor  definition   [KW-0675]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: CLEC7A
GenomeRNAi: 64581
PRO: PR:Q9BXN2