IDI2 - Isopentenyl-diphosphate delta-isomerase 2 - human protein (Function)
 
Home Recent activites arrow-down favorite My favorites arrow-down favorite My labels arrow-down Downloads
Back to ...  
Publication View
Protein
Gene
References

 
IDI2 »  Isopentenyl-diphosphate delta-isomerase 2   [ EC 5.3.3.2 ]
 
Protein also known as:  Isopentenyl pyrophosphate isomerase 2 (IPPI2).
Gene name:  IDI2
Family name: IPP isomerase type 1
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 10 1
GENE REF ISO

Function

 show evidences
Overview 
Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP).  
1
  • CuratedUniProtKB
GO molecular function 
Hydrolase activitydefinition[GO:0016787] silver  
  • IEAInterPro 2 GO
Isopentenyl-diphosphate delta-isomerase activitydefinition[GO:0004452]  
1
  • IDAMGI
Metal ion bindingdefinition[GO:0046872]  
  • IEAUniProtKB KW
GO biological process 
Dimethylallyl diphosphate biosynthetic processdefinition[GO:0050992]  
  • IEAUniPathway
Isopentenyl diphosphate metabolic processdefinition[GO:0046490]  
1
  • IDAMGI
Isoprenoid biosynthetic processdefinition[GO:0008299]  
1
  • IDAUniProtKB
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 5.3.3.2: Isopentenyl diphosphate dimethylallyl diphosphate.  
  • CuratedUniProtKB
It requires the following cofactor
Binds 1 magnesium ion per subunit (By similarity).  
  • CuratedUniProtKB
Pathways 
This protein is involved in the following pathway
According to KEGG, this protein belongs to the following pathways:
Metabolic pathways  hsa01100+91734  
Terpenoid backbone biosynthesis  hsa00900+91734  
According to Reactome, this protein belongs to the following pathway:
Metabolism  REACT_111217  
 
More information is available from:
 

Keywords

Biological process 
Cholesterol biosynthesis  definition   [KW-0152]
Cholesterol metabolism  definition   [KW-0153]
Isoprene biosynthesis  definition   [KW-0414]
Lipid biosynthesis  definition   [KW-0444]
Lipid metabolism  definition   [KW-0443]
Steroid biosynthesis  definition   [KW-0752]
Steroid metabolism  definition   [KW-0753]
Sterol biosynthesis  definition   [KW-0756]
Sterol metabolism  definition   [KW-1207]
Molecular function 
Isomerase  definition   [KW-0413]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Enzyme and pathway databases
SABIO-RK: Q9BXS1
Other
GenomeRNAi: 91734
PRO: PR:Q9BXS1