RSPO3 - R-spondin-3 - human protein (Function)
 
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Protein
Gene
References

 
RSPO3 »  R-spondin-3
 
Protein also known as:  Thrombospondin type-1 domain-containing protein 2.
Gene name:  RSPO3
Family name: R-spondin
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 17 2
GENE REF ISO

Function

 show evidences
Overview 
Activator of the canonical Wnt signaling pathway by acting as a ligand for LGR4-6 receptors. Upon binding to LGR4-6 (LGR4, LGR5 or LGR6), LGR4-6 associate with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. Also regulates the canonical Wnt/beta-catenin-dependent pathway and non-canonical Wnt signaling by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway. Acts as a ligand for frizzled FZD8 and LRP6. May negatively regulate the TGF-beta pathway.  
3
  • CuratedUniProtKB
GO molecular function 
Frizzled bindingdefinition[GO:0005109] silver  
  • IEAOrtholog Compara
Heparin bindingdefinition[GO:0008201] silver  
  • IEAOrtholog Compara
Receptor bindingdefinition[GO:0005102]  
1
  • IPIUniProtKB
GO biological process 
Branching involved in labyrinthine layer morphogenesisdefinition[GO:0060670] silver  
  • IEAOrtholog Compara
Canonical Wnt signaling pathwaydefinition[GO:0060070] silver  
  • IEAOrtholog Compara
Pathways 
According to Reactome, this protein belongs to the following pathway:
Signal Transduction  REACT_111102  
Note 
Upon injection into mice, it induces rapid onset of crypt cell proliferation involving beta-catenin stabilization. It also displays efficacy in a model of chemotherapy-induced intestinal mucositis (PubMed16357527).  
1
  • CuratedUniProtKB
 

Keywords

Biological process 
Sensory transduction  definition   [KW-0716]
Wnt signaling pathway  definition   [KW-0879]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: RSPO3
GenomeRNAi: 84870
PRO: PR:Q9BXY4