BEX2 - Protein BEX2 - human protein (Function)
 
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BEX2 »  Protein BEX2
 
Protein also known as:  Brain-expressed X-linked protein 2.
Gene name:  BEX2
Family name: BEX
Entry whose protein(s) existence is based on evidence at protein level
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1 19 2
GENE REF ISO

Function

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Overview 
Regulator of mitochondrial apoptosis and G1 cell cycle in breast cancer. Protects the breast cancer cells against mitochondrial apoptosis and this effect is mediated through the modulation of BCL2 protein family, which involves the positive regulation of anti-apoptotic member BCL2 and the negative regulation of pro-apoptotic members BAD, BAK1 and PUMA. Required for the normal cell cycle progression during G1 in breast cancer cells through the regulation of CCND1 and CDKN1A. Regulates the level of PP2A regulatory subunit B and PP2A phosphatase activity.  
1
  • CuratedUniProtKB
GO biological process 
Apoptotic processdefinition[GO:0006915]  
  • IEAUniProtKB KW
Cell cycledefinition[GO:0007049]  
  • IEAUniProtKB KW
Regulation of apoptotic processdefinition[GO:0042981]  
1
  • IDAUniProtKB
Regulation of cell cycledefinition[GO:0051726]  
1
  • IDAUniProtKB
Caution 
Was named BEX1 by some authors.  
  • CuratedUniProtKB
 

Keywords

Biological process 
Apoptosis  definition   [KW-0053]
Cell cycle  definition   [KW-0131]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: BEX2
GenomeRNAi: 84707
PRO: PR:Q9BXY8