KDM5D - Lysine-specific demethylase 5D - human protein (Function)
 
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KDM5D »  Lysine-specific demethylase 5D
 
Gene name:  KDM5D
Entry whose protein(s) existence is based on evidence at protein level
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1 30 3
GENE REF ISO

Function

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Overview 
Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'. May play a role in spermatogenesis.  
3
  • CuratedUniProtKB
GO molecular function 
DNA bindingdefinition[GO:0003677] silver  
  • IEAInterPro 2 GO
Histone demethylase activity (H3-K4 specific)definition[GO:0032453]  
1
  • IDAMGI
Oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donorsdefinition[GO:0016706] silver  
  • IEAInterPro 2 GO
Zinc ion bindingdefinition[GO:0008270] silver  
  • IEAInterPro 2 GO
GO biological process 
Histone H3-K4 demethylationdefinition[GO:0034720]  
1
  • IDAMGI
Oxidation-reduction processdefinition[GO:0055114]  
  • IEAUniProtKB KW
Enzymatic activity 
It requires the following cofactors
Ascorbate.  
1
  • CuratedUniProtKB
Binds 1 Fe(2+) ion per subunit.  
1
  • CuratedUniProtKB
 

Keywords

Molecular function 
Chromatin regulator  definition   [KW-0156]
Dioxygenase  definition   [KW-0223]
Oxidoreductase  definition   [KW-0560]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: JARID1D
GenomeRNAi: 8284
PRO: PR:Q9BY66