SHANK3 - SH3 and multiple ankyrin repeat domains protein 3 - human protein (Function)
 
Home Recent activites arrow-down favorite My favorites arrow-down favorite My labels arrow-down Downloads
Back to ...  
Publication View
Protein
Gene
References

 
SHANK3 »  SH3 and multiple ankyrin repeat domains protein 3  (Shank3)
 
Protein also known as:  Proline-rich synapse-associated protein 2 (ProSAP2).
Gene name:  SHANK3
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 24 2
GENE REF ISO

Function

 show evidences
Overview 
Major scaffold postsynaptic density protein which interacts with multiple proteins and complexes to orchestrate the dendritic spine and synapse formation, maturation and maintenance. Interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors via complexes with GKAP/PSD-95 and HOMER, respectively, and the actin-based cytoskeleton. Plays a role in the structural and functional organization of the dendritic spine and synaptic junction through the interaction with Arp2/3 and WAVE1 complex as well as the promotion of the F-actin clusters. By way of this control of actin dynamics, participates in the regulation of developing neurons growth cone motility and the NMDA receptor-signaling. Also modulates GRIA1 exocytosis and GRM5/MGLUR5 expression and signaling to control the AMPA and metabotropic glutamate receptor-mediated synaptic transmission and plasticity. May be required at an early stage of synapse formation and be inhibited by IGF1 to promote synapse maturation.  
2
  • UniProtKB
GO molecular function 
Actin bindingdefinition[GO:0003779]  
1
  • UniProtKB KW
GKAP/Homer scaffold activitydefinition[GO:0030160]  
1
  • Ortholog Curator
Identical protein bindingdefinition[GO:0042802]  
1
  • Ortholog Curator
Ionotropic glutamate receptor bindingdefinition[GO:0035255]  
1
  • Ortholog Curator
Protein bindingdefinition[GO:0005515]  
2
  • IntAct
Protein C-terminus bindingdefinition[GO:0008022]  
1
  • Ortholog Curator
Scaffold protein bindingdefinition[GO:0097110]  
1
  • Ortholog Curator
SH3 domain bindingdefinition[GO:0017124]  
1
  • Ortholog Curator
Zinc ion bindingdefinition[GO:0008270]  
1
  • Ortholog Curator
GO biological process 
Adult behaviordefinition[GO:0030534]  
2
  • BHF-UCL
Alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor clusteringdefinition[GO:0097113]  
1
  • BHF-UCL
Brain morphogenesisdefinition[GO:0048854]  
1
  • Ortholog Curator
Dendritic spine morphogenesisdefinition[GO:0060997]  
1
  • Ortholog Curator
Guanylate kinase-associated protein clusteringdefinition[GO:0097117]  
1
  • Ortholog Curator
Learningdefinition[GO:0007612]  
3
  • BHF-UCL
  • Ortholog Curator
MAPK cascadedefinition[GO:0000165]  
1
  • Ortholog Curator
Memorydefinition[GO:0007613]  
1
  • Ortholog Curator
N-methyl-D-aspartate receptor clusteringdefinition[GO:0097114]  
1
  • Ortholog Curator
Negative regulation of actin filament bundle assemblydefinition[GO:0032232]  
1
  • Ortholog Curator
Negative regulation of cell volumedefinition[GO:0045794]  
1
  • Ortholog Curator
Positive regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activitydefinition[GO:2000969]  
1
  • Ortholog Curator
Positive regulation of dendritic spine developmentdefinition[GO:0060999]  
1
  • BHF-UCL
Positive regulation of excitatory postsynaptic membrane potentialdefinition[GO:2000463]  
2
  • BHF-UCL
  • Ortholog Curator
Positive regulation of glutamate receptor signaling pathwaydefinition[GO:1900451]  
1
  • BHF-UCL
Positive regulation of long-term neuronal synaptic plasticitydefinition[GO:0048170]  
1
  • Ortholog Curator
Positive regulation of synapse structural plasticitydefinition[GO:0051835]  
1
  • Ortholog Curator
Positive regulation of synaptic transmission, glutamatergicdefinition[GO:0051968]  
1
  • BHF-UCL
Postsynaptic density assemblydefinition[GO:0097107]  
1
  • Ortholog Curator
Regulation of dendritic spine morphogenesisdefinition[GO:0061001]  
1
  • BHF-UCL
Regulation of long term synaptic depressiondefinition[GO:1900452]  
1
  • BHF-UCL
Regulation of long-term synaptic potentiationdefinition[GO:1900271]  
1
  • Ortholog Curator
Social behaviordefinition[GO:0035176]  
3
  • BHF-UCL
  • Ortholog Curator
Striatal medium spiny neuron differentiationdefinition[GO:0021773]  
1
  • Ortholog Curator
Synapse assemblydefinition[GO:0007416]  
1
  • Ortholog Curator
Vocal learningdefinition[GO:0042297]  
2
  • BHF-UCL
Vocalization behaviordefinition[GO:0071625]  
3
  • BHF-UCL
 

Keywords

Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: SHANK3
GenomeRNAi: 85358
PRO: PR:Q9BYB0