SHANK3 - SH3 and multiple ankyrin repeat domains protein 3 - human protein (Function)
 
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SHANK3 »  SH3 and multiple ankyrin repeat domains protein 3  (Shank3)
 
Protein also known as:  Proline-rich synapse-associated protein 2 (ProSAP2).
Gene name:  SHANK3
Entry whose protein(s) existence is based on evidence at protein level
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1 24 2
GENE REF ISO

Function

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Overview 
Major scaffold postsynaptic density protein which interacts with multiple proteins and complexes to orchestrate the dendritic spine and synapse formation, maturation and maintenance. Interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors via complexes with GKAP/PSD-95 and HOMER, respectively, and the actin-based cytoskeleton. Plays a role in the structural and functional organization of the dendritic spine and synaptic junction through the interaction with Arp2/3 and WAVE1 complex as well as the promotion of the F-actin clusters. By way of this control of actin dynamics, participates in the regulation of developing neurons growth cone motility and the NMDA receptor-signaling. Also modulates GRIA1 exocytosis and GRM5/MGLUR5 expression and signaling to control the AMPA and metabotropic glutamate receptor-mediated synaptic transmission and plasticity. May be required at an early stage of synapse formation and be inhibited by IGF1 to promote synapse maturation.  
1
  • CuratedUniProtKB
GO molecular function 
Actin bindingdefinition[GO:0003779]  
  • IEAUniProtKB KW
GKAP/Homer scaffold activitydefinition[GO:0030160]  
  • ISSOrtholog Curator
Identical protein bindingdefinition[GO:0042802]  
  • ISSOrtholog Curator
Ionotropic glutamate receptor bindingdefinition[GO:0035255]  
  • ISSOrtholog Curator
Protein bindingdefinition[GO:0005515]  
2
  • IPIIntAct
Protein C-terminus bindingdefinition[GO:0008022]  
  • ISSOrtholog Curator
Scaffold protein bindingdefinition[GO:0097110]  
  • ISSOrtholog Curator
SH3 domain bindingdefinition[GO:0017124]  
  • ISSOrtholog Curator
Zinc ion bindingdefinition[GO:0008270]  
  • ISSOrtholog Curator
GO biological process 
Adult behaviordefinition[GO:0030534]  
2
  • IMPBHF-UCL
Alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor clusteringdefinition[GO:0097113]  
1
  • ISSBHF-UCL
Brain morphogenesisdefinition[GO:0048854]  
  • ISSOrtholog Curator
Dendritic spine morphogenesisdefinition[GO:0060997]  
  • ISSOrtholog Curator
Guanylate kinase-associated protein clusteringdefinition[GO:0097117]  
  • ISSOrtholog Curator
Learningdefinition[GO:0007612]  
2
  • IMPBHF-UCL
  • ISSOrtholog Curator
MAPK cascadedefinition[GO:0000165]  
  • ISSOrtholog Curator
Memorydefinition[GO:0007613]  
  • ISSOrtholog Curator
N-methyl-D-aspartate receptor clusteringdefinition[GO:0097114]  
  • ISSOrtholog Curator
Negative regulation of actin filament bundle assemblydefinition[GO:0032232]  
  • ISSOrtholog Curator
Negative regulation of cell volumedefinition[GO:0045794]  
  • ISSOrtholog Curator
Positive regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activitydefinition[GO:2000969]  
  • ISSOrtholog Curator
Positive regulation of dendritic spine developmentdefinition[GO:0060999]  
1
  • ISSBHF-UCL
Positive regulation of excitatory postsynaptic membrane potentialdefinition[GO:2000463]  
1
  • ISSBHF-UCL
  • ISSOrtholog Curator
Positive regulation of glutamate receptor signaling pathwaydefinition[GO:1900451]  
1
  • ISSBHF-UCL
Positive regulation of long-term neuronal synaptic plasticitydefinition[GO:0048170]  
  • ISSOrtholog Curator
Positive regulation of synapse structural plasticitydefinition[GO:0051835]  
  • ISSOrtholog Curator
Positive regulation of synaptic transmission, glutamatergicdefinition[GO:0051968]  
1
  • ISSBHF-UCL
Postsynaptic density assemblydefinition[GO:0097107]  
  • ISSOrtholog Curator
Regulation of dendritic spine morphogenesisdefinition[GO:0061001]  
1
  • ISSBHF-UCL
Regulation of long term synaptic depressiondefinition[GO:1900452]  
1
  • ISSBHF-UCL
Regulation of long-term synaptic potentiationdefinition[GO:1900271]  
  • ISSOrtholog Curator
Social behaviordefinition[GO:0035176]  
2
  • IMPBHF-UCL
  • ISSOrtholog Curator
Striatal medium spiny neuron differentiationdefinition[GO:0021773]  
  • ISSOrtholog Curator
Synapse assemblydefinition[GO:0007416]  
  • ISSOrtholog Curator
Vocal learningdefinition[GO:0042297]  
2
  • IMPBHF-UCL
Vocalization behaviordefinition[GO:0071625]  
3
  • IMPBHF-UCL
 

Keywords

Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: SHANK3
GenomeRNAi: 85358
PRO: PR:Q9BYB0