FUT8 - Alpha-(1,6)-fucosyltransferase - human protein (Function)
 
Home Recent activites arrow-down favorite My favorites arrow-down favorite My labels arrow-down Downloads
Back to ...  
Publication View
Protein
Gene
References

 
FUT8 »  Alpha-(1,6)-fucosyltransferase   [ EC 2.4.1.68 ]  (Alpha1-6FucT)
 
Protein also known as:  GDP-L-Fuc:N-acetyl-beta-D-glucosaminide alpha1,6-fucosyltransferase.
Gene name:  FUT8
Family name: Glycosyltransferase 23
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 27 4
GENE REF ISO

Function

 show evidences
Overview 
Catalyzes the addition of fucose in alpha 1-6 linkage to the first GlcNAc residue, next to the peptide chains in N-glycans.  
2
  • CuratedUniProtKB
GO molecular function 
Glycoprotein 6-alpha-L-fucosyltransferase activitydefinition[GO:0008424]  
2
  • IDAUniProtKB
SH3 domain bindingdefinition[GO:0017124]  
  • IEAUniProtKB KW
GO biological process 
Cell migrationdefinition[GO:0016477] silver  
  • IEAOrtholog Compara
GDP-L-fucose metabolic processdefinition[GO:0046368]  
1
  • IDAUniProtKB
In utero embryonic developmentdefinition[GO:0001701]  
1
  • NASUniProtKB
Integrin-mediated signaling pathwaydefinition[GO:0007229] silver  
  • IEAOrtholog Compara
L-fucose catabolic processdefinition[GO:0042355]  
1
  • NASUniProtKB
N-glycan fucosylationdefinition[GO:0036071]  
3
  • IDAGOC
  • IEAEC 2 GO
  • IEAInterPro 2 GO
N-glycan processingdefinition[GO:0006491]  
1
  • TASUniProtKB
Oligosaccharide biosynthetic processdefinition[GO:0009312]  
1
  • TASPINC
Protein glycosylation in Golgidefinition[GO:0033578] silver  
  • IEAInterPro 2 GO
Protein N-linked glycosylationdefinition[GO:0006487]  
1
  • TASPINC
Protein N-linked glycosylation via asparaginedefinition[GO:0018279]  
1
  • IDAUniProtKB
Receptor metabolic processdefinition[GO:0043112] silver  
  • IEAOrtholog Compara
Respiratory gaseous exchangedefinition[GO:0007585] silver  
  • IEAOrtholog Compara
Transforming growth factor beta receptor signaling pathwaydefinition[GO:0007179] silver  
  • IEAOrtholog Compara
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.4.1.68: GDP-beta-L-fucose + N(4)-(N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-(N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6))-beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl)asparagine GDP + N(4)-(N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-(N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6))-beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-(alpha-L-fucosyl-(1->6))-N-acetyl-beta-D-glucosaminyl)asparagine.  
1
  • CuratedUniProtKB
According to CAZy, this protein is belongs to the following pathway:
Glycosyltransferase Family 23  GT23  
 
More information is available from:
Pathways 
This protein is involved in the following pathway
According to KEGG, this protein belongs to the following pathways:
Glycosaminoglycan biosynthesis - keratan sulfate  hsa00533+2530  
Metabolic pathways  hsa01100+2530  
N-Glycan biosynthesis  hsa00510+2530  
According to Reactome, this protein belongs to the following pathway:
Reactions specific to the complex N-glycan synthesis pathway  REACT_25302  
 

Keywords

Molecular function 
Glycosyltransferase  definition   [KW-0328]
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: FUT8
GenomeRNAi: 2530
PRO: PR:Q9BYC5