ACE2 - Angiotensin-converting enzyme 2 - human protein (Function)
 
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ACE2 »  Angiotensin-converting enzyme 2   [ EC 3.4.17.23 ]
 
Protein also known as:  Angiotensin-converting enzyme homolog (ACEH). Cleaved into:  Processed angiotensin-converting enzyme 2.
Gene name:  ACE2
Family name: Peptidase M2
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 184 2
GENE REF ISO

Function

 show evidences
Overview 
Carboxypeptidase which converts angiotensin I to angiotensin 1-9, a peptide of unknown function, and angiotensin II to angiotensin 1-7, a vasodilator. Also able to hydrolyze apelin-13 and dynorphin-13 with high efficiency. May be an important regulator of heart function. In case of human coronaviruses SARS and HCoV-NL63 infections, serve as functional receptor for the spike glycoprotein of both coronaviruses.  
4
  • CuratedUniProtKB
GO molecular function 
Carboxypeptidase activitydefinition[GO:0004180]  
4
  • IDABHF-UCL
  • IDAUniProtKB
Endopeptidase activitydefinition[GO:0004175]  
1
  • IDAUniProtKB
Glycoprotein bindingdefinition[GO:0001948]  
1
  • IPIBHF-UCL
Not  Metallopeptidase activitydefinition[GO:0008237]  
1
  • IDAUniProtKB
Peptide hormone bindingdefinition[GO:0017046] silver  
  • IEAOrtholog Compara
Not  Peptidyl-dipeptidase activitydefinition[GO:0008241]  
1
  • IDAUniProtKB
Protein bindingdefinition[GO:0005515]  
1
  • IPIUniProtKB
Virus receptor activitydefinition[GO:0001618]  
2
  • IMPUniProtKB
  • IDABHF-UCL
Zinc ion bindingdefinition[GO:0008270]  
1
  • TASBHF-UCL
GO biological process 
Angiotensin catabolic process in blooddefinition[GO:0002005]  
1
  • ICBHF-UCL
Angiotensin-mediated drinking behaviordefinition[GO:0003051]  
1
  • IMPBHF-UCL
Positive regulation of reactive oxygen species metabolic processdefinition[GO:2000379]  
1
  • ICBHF-UCL
Proteolysisdefinition[GO:0006508]  
  • IEAUniProtKB KW
Receptor biosynthetic processdefinition[GO:0032800]  
1
  • IMPBHF-UCL
Receptor-mediated virion attachment to host celldefinition[GO:0046813]  
1
  • IDABHF-UCL
Regulation of cell proliferationdefinition[GO:0042127]  
1
  • TASBHF-UCL
Regulation of cytokine productiondefinition[GO:0001817]  
1
  • ICBHF-UCL
Regulation of inflammatory responsedefinition[GO:0050727]  
1
  • ICBHF-UCL
Regulation of systemic arterial blood pressure by renin-angiotensindefinition[GO:0003081]  
2
  • IMPBHF-UCL
Regulation of vasoconstrictiondefinition[GO:0019229]  
1
  • ICBHF-UCL
Regulation of vasodilationdefinition[GO:0042312]  
1
  • ICBHF-UCL
Response to virusdefinition[GO:0009615]  
2
  • IMPGOC
Viral entry into host celldefinition[GO:0046718]  
1
  • TASUniProtKB
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 3.4.17.23: Angiotensin II + H(2)O angiotensin-(1-7) + L-phenylalanine.  
  • CuratedUniProtKB
It requires the following cofactors
Binds 1 zinc ion per subunit.  
1
  • CuratedUniProtKB
Binds 1 chloride ion per subunit.  
1
  • CuratedUniProtKB
It is regulated in the following manner
Activated by chloride and fluoride, but not bromide. Inhibited by MLN-4760, cFP_Leu, and EDTA, but not by the ACE inhibitors linosipril, captopril and enalaprilat.  
4
  • CuratedUniProtKB
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathways:
Protein digestion and absorption  hsa04974+59272  
Renin-angiotensin system  hsa04614+59272  
According to Reactome, this protein belongs to the following pathway:
Metabolism of Angiotensinogen to Angiotensins  REACT_147707  
 

Biophysicochemical properties

Kinetic parameters
KM 6.8 uM for apelin-13
KM 2 uM for angiotensin II
KM 6.9 uM for angiotensin I
KM 5.5 uM for dynorphin-13
Dependence
pH Optimum pH is 6.5 in the presence of 1 M NaCl. Active from pH 6 to 9.

Keywords

Biological process 
Host-virus interaction  definition   [KW-0945]
Molecular function 
Carboxypeptidase  definition   [KW-0121]
Hydrolase  definition   [KW-0378]
Metalloprotease  definition   [KW-0482]
Protease  definition   [KW-0645]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Enzyme and pathway databases
SABIO-RK: Q9BYF1
Other
GeneWiki: Angiotensin-converting_enzyme_2
GenomeRNAi: 59272
PRO: PR:Q9BYF1
Chemistry
GuidetoPHARMACOLOGY: 1614