ANO3 - Anoctamin-3 - human protein (Function)
 
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Protein
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ANO3 »  Anoctamin-3
 
Protein also known as:  Transmembrane protein 16C.
Gene name:  ANO3
Family name: Anoctamin
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 36 2
GENE REF ISO

Function

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Overview 
Has calcium-dependent phospholipid scramblase activity; scrambles phosphatidylcholine and galactosylceramide. Seems to act as potassium channel regulator and may inhibit pain signaling; can facilitate KCNT1/Slack channel activity by promoting its full single-channel conductance at very low sodium concentrations and by increasing its sodium sensitivity (By similarity). Does not exhibit calcium-activated chloride channel (CaCC) activity.  
3
  • UniProtKB
GO molecular function 
Not  Intracellular calcium activated chloride channel activitydefinition[GO:0005229]  
1
  • UniProtKB
Phospholipid scramblase activitydefinition[GO:0017128] silver  
1
  • Ortholog Compara
GO biological process 
Calcium activated galactosylceramide scramblingdefinition[GO:0061591] silver  
1
  • Ortholog Compara
Calcium activated phosphatidylcholine scramblingdefinition[GO:0061590] silver  
1
  • Ortholog Compara
Lipid transportdefinition[GO:0006869]  
1
  • UniProtKB KW
Pathways 
According to Reactome, this protein belongs to the following pathways:
Orphan transporters  REACT_267716  
Stimuli-sensing channels  REACT_160189  
Note 
The term 'anoctamin' was coined because these channels are anion selective and have eight (OCT) transmembrane segments. There is some dissatisfaction in the field with the Ano nomenclature because it is not certain that all the members of this family are anion channels or have the 8-transmembrane topology.  
1
  • UniProtKB
 

Keywords

Biological process 
Lipid transport  definition   [KW-0445]
Transport  definition   [KW-0813]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 63982
PRO: PR:Q9BYT9