AGXT2 - Alanine--glyoxylate aminotransferase 2, mitochondrial - human protein (Function)
 
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Protein
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AGXT2 »  Alanine--glyoxylate aminotransferase 2, mitochondrial   [ EC 2.6.1.44 ]  (AGT 2)
 
Protein also known as:  (R)-3-amino-2-methylpropionate--pyruvate transaminase [EC 2.6.1.40].
Gene name:  AGXT2
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 17 1
GENE REF ISO

Function

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Overview 
Can metabolize asymmetric dimethylarginine (ADMA) via transamination to alpha-keto-delta-(NN-dimethylguanidino) valeric acid (DMGV). ADMA is a potent inhibitor of nitric-oxide (NO) synthase, and this activity provides mechanism through which the kidney regulates blood pressure.  
2
  • CuratedUniProtKB
GO molecular function 
(R)-3-amino-2-methylpropionate-pyruvate transaminase activitydefinition[GO:0047305]  
  • IEAEC 2 GO
Alanine-glyoxylate transaminase activitydefinition[GO:0008453]  
1
  • IDABHF-UCL
Beta-alanine-pyruvate transaminase activitydefinition[GO:0016223] silver  
  • IEAOrtholog Compara
Pyridoxal phosphate bindingdefinition[GO:0030170] silver  
  • IEAInterPro 2 GO
GO biological process 
Glycine biosynthetic process, by transamination of glyoxylatedefinition[GO:0019265]  
1
  • IDABHF-UCL
Glyoxylate catabolic processdefinition[GO:0009436]  
1
  • IDABHF-UCL
L-alanine catabolic process, by transaminationdefinition[GO:0019481]  
1
  • IDABHF-UCL
Positive regulation of nitric oxide biosynthetic processdefinition[GO:0045429]  
1
  • IDABHF-UCL
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reactions
EC 2.6.1.44: L-alanine + glyoxylate pyruvate + glycine.  
  • CuratedUniProtKB
EC 2.6.1.40: (R)-3-amino-2-methylpropanoate + pyruvate 2-methyl-3-oxopropanoate + L-alanine.  
  • CuratedUniProtKB
It requires the following cofactor
Pyridoxal phosphate.  
  • CuratedUniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathways:
Alanine, aspartate and glutamate metabolism  hsa00250+64902  
Glycine, serine and threonine metabolism  hsa00260+64902  
Metabolic pathways  hsa01100+64902  
According to Reactome, this protein belongs to the following pathway:
Metabolism  REACT_111217  
 
More information is available from:
 

Keywords

Molecular function 
Aminotransferase  definition   [KW-0032]
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 64902
PRO: PR:Q9BYV1