BACH2 - Transcription regulator protein BACH2 - human protein (Function)
 
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Gene
References

 
BACH2 »  Transcription regulator protein BACH2
 
Protein also known as:  BTB and CNC homolog 2.
Gene name:  BACH2
Family name: bZIP » CNC
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Transcriptional regulator that acts as repressor or activator. Binds to Maf recognition elements (MARE). Play important roles in coordinating transcription activation and repression by MAFK (By similarity). Induces apoptosis in response to oxidative stress through repression of the antiapoptotic factor HMOX1.  
2
  • UniProtKB
GO molecular function 
RNA polymerase II distal enhancer sequence-specific DNA bindingdefinition[GO:0000980]  
1
  • RefGenome
Transcription factor activity, sequence-specific DNA bindingdefinition[GO:0003700]  
1
  • RefGenome
Transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific bindingdefinition[GO:0001206] silver  
1
  • Ortholog Compara
Contributes to ubiquitin-protein transferase activitydefinition[GO:0004842]  
1
  • RefGenome
GO biological process 
Negative regulation of transcription from RNA polymerase II promoterdefinition[GO:0000122] silver  
1
  • Ortholog Compara
Protein ubiquitinationdefinition[GO:0016567]  
1
  • RefGenome
Regulation of transcription, DNA-templateddefinition[GO:0006355]  
1
  • RefGenome
Transcription from RNA polymerase II promoterdefinition[GO:0006366]  
1
  • RefGenome
 

Keywords

Biological process 
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Molecular function 
Activator  definition   [KW-0010]
Repressor  definition   [KW-0678]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: BACH2
GenomeRNAi: 60468
PRO: PR:Q9BYV9