IFIH1 - Interferon-induced helicase C domain-containing protein 1 - human protein (Function)
 
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IFIH1 »  Interferon-induced helicase C domain-containing protein 1   [ EC 3.6.4.13 ]
 
Protein also known as:  Clinically amyopathic dermatomyositis autoantigen 140 kDa (CADM-140 autoantigen).
Gene name:  IFIH1
Family name: Helicase » RLR
Entry whose protein(s) existence is based on evidence at protein level
extend overview
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GENE REF ISO

Function

 show evidences
Overview 
Innate immune receptor which acts as a cytoplasmic sensor of viral nucleic acids and plays a major role in sensing viral infection and in the activation of a cascade of antiviral responses including the induction of type I interferons and proinflammatory cytokines. Its ligands include mRNA lacking 2'-O-methylation at their 5' cap and long-dsRNA (>1 kb in length). Upon ligand binding it associates with mitochondria antiviral signaling protein (MAVS/IPS1) which activates the IKK-related kinases: TBK1 and IKBKE which phosphorylate interferon regulatory factors: IRF3 and IRF7 which in turn activate transcription of antiviral immunological genes, including interferons (IFNs); IFN-alpha and IFN-beta. Responsible for detecting the Picornaviridae family members such as encephalomyocarditis virus (EMCV) and mengo encephalomyocarditis virus (ENMG). Can also detect other viruses such as dengue virus (DENV), west Nile virus (WNV), and reovirus. Also involved in antiviral signaling in response to viruses containing a dsDNA genome, such as vaccinia virus. Plays an important role in amplifying innate immune signaling through recognition of RNA metabolites that are produced during virus infection by ribonuclease L (RNase L). May play an important role in enhancing natural killer cell function and may be involved in growth inhibition and apoptosis in several tumor cell lines.  
5
  • CuratedUniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524]  
  • IEAUniProtKB KW
DNA bindingdefinition[GO:0003677] silver  
  • IEAInterPro 2 GO
Double-stranded RNA bindingdefinition[GO:0003725]  
2
  • IDAUniProtKB
  • TASBHF-UCL
Helicase activitydefinition[GO:0004386]  
  • IEAUniProtKB KW
Protein bindingdefinition[GO:0005515]  
8
  • IPIIntAct
  • IPIUniProtKB
  • IPIBHF-UCL
Ribonucleoprotein complex bindingdefinition[GO:0043021]  
1
  • IPIUniProtKB
Single-stranded RNA bindingdefinition[GO:0003727]  
1
  • IDAUniProtKB
Zinc ion bindingdefinition[GO:0008270]  
2
  • IDAUniProtKB
GO biological process 
Cytoplasmic pattern recognition receptor signaling pathway in response to virusdefinition[GO:0039528]  
1
  • TASUniProtKB
Detection of virusdefinition[GO:0009597]  
1
  • TASBHF-UCL
Innate immune responsedefinition[GO:0045087]  
1
  • TASUniProtKB
Positive regulation of interferon-alpha productiondefinition[GO:0032727]  
2
  • IMPUniProtKB
  • TASBHF-UCL
Positive regulation of interferon-beta productiondefinition[GO:0032728]  
3
  • IMPUniProtKB
  • TASBHF-UCL
Protein sumoylationdefinition[GO:0016925]  
1
  • IDAUniProtKB
Regulation of apoptotic processdefinition[GO:0042981] silver  
  • IEAInterPro 2 GO
Regulation of type III interferon productiondefinition[GO:0034344]  
1
  • TASUniProtKB
Response to virusdefinition[GO:0009615]  
1
  • TASUniProtKB
Viral processdefinition[GO:0016032]  
  • IEAUniProtKB KW
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 3.6.4.13: ATP + H(2)O ADP + phosphate.  
  • CuratedUniProtKB
It requires the following cofactor
Zinc.  
  • CuratedUniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathways:
Herpes simplex infection  hsa05168+64135  
Influenza A  hsa05164+64135  
Measles  hsa05162+64135  
RIG-I-like receptor signaling pathway  hsa04622+64135  
According to Reactome, this protein belongs to the following pathway:
Immune System  REACT_6900  
Note 
In HIV-1 infected HeLa-CD4 cells, overexpression of IFIH1 results in a great increase in the level of secreted viral p24 protein.  
  • CuratedUniProtKB
 

Keywords

Biological process 
Antiviral defense  definition   [KW-0051]
Host-virus interaction  definition   [KW-0945]
Immunity  definition   [KW-0391]
Innate immunity  definition   [KW-0399]
Molecular function 
Helicase  definition   [KW-0347]
Hydrolase  definition   [KW-0378]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: MDA5
GenomeRNAi: 64135
PRO: PR:Q9BYX4