ABCA2 - ATP-binding cassette sub-family A member 2 - human protein (Function)
 
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Protein
Gene
References

 
ABCA2 »  ATP-binding cassette sub-family A member 2
 
Protein also known as:  ATP-binding cassette transporter 2 (ATP-binding cassette 2).
Gene name:  ABCA2
Family name: ABC transporter » ABCA
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Probable transporter, its natural substrate has not been found yet. May have a role in macrophage lipid metabolism and neural development.  
1
  • UniProtKB
According to TCDB this is a transporter from family:
the atp-binding cassette (abc) superfamily  3.A.1.211.3  
GO molecular function 
ATP bindingdefinition[GO:0005524]  
2
  • UniProtKB
  • Ortholog Curator
ATPase activitydefinition[GO:0016887]  
1
  • UniProtKB
ATPase activity, coupled to transmembrane movement of substancesdefinition[GO:0042626]  
2
  • UniProtKB
  • RefGenome
Nucleotide bindingdefinition[GO:0000166]  
1
  • UniProtKB
GO biological process 
Cholesterol homeostasisdefinition[GO:0042632]  
1
  • UniProtKB
Lipid metabolic processdefinition[GO:0006629]  
1
  • UniProtKB
Regulation of intracellular cholesterol transportdefinition[GO:0032383]  
1
  • UniProtKB
Regulation of transcription from RNA polymerase II promoterdefinition[GO:0006357]  
1
  • UniProtKB
Response to drugdefinition[GO:0042493]  
1
  • UniProtKB
Response to steroid hormonedefinition[GO:0048545]  
1
  • UniProtKB
Transmembrane transportdefinition[GO:0055085]  
1
  • RefGenome
Transportdefinition[GO:0006810]  
2
  • UniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathways:
ABC transporters  hsa02010+20  
Lysosome  hsa04142+20  
According to Reactome, this protein belongs to the following pathway:
ABCA transporters in lipid homeostasis  REACT_111158  
 

Keywords

Biological process 
Transport  definition   [KW-0813]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: ABCA2
GenomeRNAi: 20
PRO: PR:Q9BZC7