GSX2 - GS homeobox 2 - human protein (Function)
 
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Protein
Gene
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GSX2 »  GS homeobox 2
 
Protein also known as:  Genetic-screened homeobox 2.
Gene name:  GSX2
Family name: Antp homeobox
Entry whose protein(s) existence is based on evidence at transcript level
extend overview
1 16 1
GENE REF ISO

Function

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Overview 
During telencephalic development, causes ventralization of pallial progenitors and, depending on the developmental stage, specifies different neuronal fates. At early stages, necessary and sufficient to correctly specify the ventral lateral ganglionic eminence (LGE) and its major derivatives, the striatal projection neurons. At later stages, may specify LGE progenitors toward dorsal LGE fates, including olfactory bulb interneurons (By similarity). Transcription factor that binds 5'-CNAATTAG-3' DNA sequence.  
2
  • UniProtKB
GO molecular function 
Sequence-specific DNA bindingdefinition[GO:0043565] silver  
1
  • InterPro 2 GO
GO biological process 
Forebrain dorsal/ventral pattern formationdefinition[GO:0021798] silver  
1
  • Ortholog Compara
Forebrain morphogenesisdefinition[GO:0048853] silver  
1
  • Ortholog Compara
Hindbrain morphogenesisdefinition[GO:0021575] silver  
1
  • Ortholog Compara
Neuron fate specificationdefinition[GO:0048665] silver  
1
  • Ortholog Compara
Olfactory bulb interneuron differentiationdefinition[GO:0021889] silver  
1
  • Ortholog Compara
Positive regulation of Notch signaling pathwaydefinition[GO:0045747] silver  
1
  • Ortholog Compara
Positive regulation of oligodendrocyte differentiationdefinition[GO:0048714] silver  
1
  • Ortholog Compara
Regulation of cell migrationdefinition[GO:0030334] silver  
1
  • Ortholog Compara
Regulation of respiratory gaseous exchange by neurological system processdefinition[GO:0002087] silver  
1
  • Ortholog Compara
Regulation of transcription, DNA-templateddefinition[GO:0006355]  
1
  • UniProtKB KW
Spinal cord association neuron differentiationdefinition[GO:0021527] silver  
1
  • Ortholog Compara
Subpallium neuron fate commitmentdefinition[GO:0060163] silver  
1
  • Ortholog Compara
Telencephalon regionalizationdefinition[GO:0021978] silver  
1
  • Ortholog Compara
Transcription, DNA-templateddefinition[GO:0006351]  
1
  • UniProtKB KW
 

Keywords

Biological process 
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Molecular function 
Developmental protein  definition   [KW-0217]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 170825
PRO: PR:Q9BZM3