CD244 - Natural killer cell receptor 2B4 - human protein (Function)
 
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Protein
Gene
References

 
CD244 »  Natural killer cell receptor 2B4
 
Protein also known as:  Signaling lymphocytic activation molecule 4; CD antigen CD244.
Gene name:  CD244
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 84 4
GENE REF ISO

Function

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Overview 
Modulate other receptor-ligand interactions to enhance leukocyte activation. CD244/2B4 is the only heterophilic receptor of SLAM family.  
2
  • UniProtKB
GO molecular function 
MHC class I protein bindingdefinition[GO:0042288]  
1
  • UniProtKB
Protein bindingdefinition[GO:0005515]  
1
  • IntAct
Receptor activitydefinition[GO:0004872] silver  
1
  • InterPro 2 GO
GO biological process 
Natural killer cell activation involved in immune responsedefinition[GO:0002323]  
1
  • UniProtKB
Positive regulation of granzyme B productiondefinition[GO:0071663]  
1
  • UniProtKB
Positive regulation of inositol phosphate biosynthetic processdefinition[GO:0060732]  
1
  • UniProtKB
Positive regulation of interferon-gamma secretiondefinition[GO:1902715]  
1
  • UniProtKB
Positive regulation of interleukin-8 secretiondefinition[GO:2000484]  
1
  • UniProtKB
Signal transductiondefinition[GO:0007165]  
1
  • PINC
Pathways 
According to KEGG, this protein belongs to the following pathway:
Natural killer cell mediated cytotoxicity  hsa04650+51744  
According to Reactome, this protein belongs to the following pathway:
Cell surface interactions at the vascular wall  R-HSA-202733  
 

Keywords

Molecular function 
Receptor  definition   [KW-0675]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: CD244
GenomeRNAi: 51744
PRO: PR:Q9BZW8