TRIM4 - E3 ubiquitin-protein ligase TRIM4 - human protein (Function)
 
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TRIM4 »  E3 ubiquitin-protein ligase TRIM4   [ EC 6.3.2.- ]
 
Protein also known as:  Tripartite motif-containing protein 4.
Gene name:  TRIM4
Family name: TRIM/RBCC
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
E3 ubiquitin-protein ligase. Mediates 'Lys-63'-linked polyubiquitination of the innate immune receptor DDX58, this linkage doesn't lead to proteasomal degradation but seems to enhance IFN induction.  
2
  • UniProtKB
GO molecular function 
Ligase activitydefinition[GO:0016874]  
1
  • UniProtKB KW
Zinc ion bindingdefinition[GO:0008270] silver  
1
  • InterPro 2 GO
GO biological process 
Innate immune responsedefinition[GO:0045087]  
1
  • UniProtKB KW
Protein trimerizationdefinition[GO:0070206]  
1
  • UniProtKB
Protein ubiquitinationdefinition[GO:0016567]  
1
  • UniPathway
Pathways 
This protein is involved in the following pathway
Protein modification; protein ubiquitination  
1
  • UniProtKB
 

Keywords

Biological process 
Immunity  definition   [KW-0391]
Innate immunity  definition   [KW-0399]
Ubl conjugation pathway  definition   [KW-0833]
Molecular function 
Ligase  definition   [KW-0436]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 89122
PRO: PR:Q9C037