PHACTR1 - Phosphatase and actin regulator 1 - human protein (Function)
 
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PHACTR1 »  Phosphatase and actin regulator 1
 
Gene name:  PHACTR1
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Binds actin monomers (G actin) and plays a role in the reorganization of the actin cytoskeleton and in formation of actin stress fibers. Plays a role in cell motility. Plays a role in the formation of tubules by endothelial cells. Regulates PPP1CA activity. Required for normal cell survival.  
3
  • UniProtKB
GO molecular function 
Actin bindingdefinition[GO:0003779]  
1
  • Ortholog Curator
Protein phosphatase 1 bindingdefinition[GO:0008157] silver  
1
  • InterPro 2 GO
Protein phosphatase inhibitor activitydefinition[GO:0004864]  
1
  • UniProtKB KW
Protein phosphatase type 1 regulator activitydefinition[GO:0008599] silver  
1
  • InterPro 2 GO
GO biological process 
Actin cytoskeleton reorganizationdefinition[GO:0031532]  
1
  • Ortholog Curator
Actomyosin structure organizationdefinition[GO:0031032]  
1
  • UniProtKB
Cell motilitydefinition[GO:0048870]  
1
  • UniProtKB
Negative regulation of catalytic activitydefinition[GO:0043086]  
1
  • UniProtKB KW
Stress fiber assemblydefinition[GO:0043149]  
1
  • UniProtKB
 

Keywords

Molecular function 
Protein phosphatase inhibitor  definition   [KW-0650]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 221692
PRO: PR:Q9C0D0