BHLHE41 - Class E basic helix-loop-helix protein 41 - human protein (Function)
 
Home Recent activites arrow-down favorite My favorites arrow-down favorite My labels arrow-down Downloads
Back to ...  
Publication View
Protein
Gene
References

 
BHLHE41 »  Class E basic helix-loop-helix protein 41  (bHLHe41)
 
Protein also known as:  Differentially expressed in chondrocytes protein 2.
Gene name:  BHLHE41
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 25 1
GENE REF ISO

Function

 show evidences
Overview 
May be a transcriptional repressor that represses both basal and activated transcription.  
1
  • CuratedUniProtKB
GO molecular function 
bHLH transcription factor bindingdefinition[GO:0043425]  
1
  • IPIBHF-UCL
  • ISSOrtholog Curator
E-box bindingdefinition[GO:0070888]  
2
  • IDABHF-UCL
  • ISSOrtholog Curator
Histone deacetylase bindingdefinition[GO:0042826]  
  • ISSOrtholog Curator
MRF bindingdefinition[GO:0043426]  
  • ISSOrtholog Curator
Protein heterodimerization activitydefinition[GO:0046982]  
1
  • IPIBHF-UCL
  • ISSOrtholog Curator
Protein homodimerization activitydefinition[GO:0042803]  
  • ISSOrtholog Curator
RNA polymerase II activating transcription factor bindingdefinition[GO:0001102]  
  • ISSOrtholog Curator
RNA polymerase II core promoter proximal region sequence-specific DNA bindingdefinition[GO:0000978]  
  • ISSOrtholog Curator
RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcriptiondefinition[GO:0001078]  
  • ISSOrtholog Curator
RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activitydefinition[GO:0003705]  
  • ISSOrtholog Curator
RNA polymerase II transcription factor binding transcription factor activity involved in negative regulation of transcriptiondefinition[GO:0001191]  
  • ISSOrtholog Curator
GO biological process 
Cell differentiationdefinition[GO:0030154]  
1
  • NASUniProtKB
Cell proliferationdefinition[GO:0008283]  
1
  • NASUniProtKB
Circadian regulation of gene expressiondefinition[GO:0032922] silver  
  • IEAOrtholog Compara
Negative regulation of myotube differentiationdefinition[GO:0010832]  
  • ISSOrtholog Curator
Negative regulation of transcription by competitive promoter bindingdefinition[GO:0010944]  
  • ISSOrtholog Curator
Negative regulation of transcription from RNA polymerase II promoterdefinition[GO:0000122]  
2
  • IDABHF-UCL
Negative regulation of transcription, DNA-templateddefinition[GO:0045892]  
  • ISSOrtholog Curator
Organ morphogenesisdefinition[GO:0009887]  
1
  • NASUniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathway:
Circadian rhythm - mammal  hsa04710+79365  
According to Reactome, this protein belongs to the following pathway:
Circadian Clock  REACT_24941  
 

Keywords

Biological process 
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Molecular function 
Repressor  definition   [KW-0678]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: BHLHB3
GenomeRNAi: 79365
PRO: PR:Q9C0J9