BCL11B - B-cell lymphoma/leukemia 11B - human protein (Function)
 
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Protein
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BCL11B »  B-cell lymphoma/leukemia 11B  (BCL-11B)
 
Protein also known as:  Radiation-induced tumor suppressor gene 1 protein.
Gene name:  BCL11B
Entry whose protein(s) existence is based on evidence at protein level
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1 49 2
GENE REF ISO

Function

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Overview 
Tumor-suppressor protein involved in T-cell lymphomas. May function on the P53-signaling pathway. May be a key regulator of both differentiation and survival during thymocyte development. Repress transcription through direct, TFCOUP2-independent binding to a GC-rich response element (By similarity).  
  • CuratedUniProtKB
GO molecular function 
Metal ion bindingdefinition[GO:0046872]  
  • IEAUniProtKB KW
Protein bindingdefinition[GO:0005515]  
2
  • IPIIntAct
RNA polymerase II core promoter proximal region sequence-specific DNA bindingdefinition[GO:0000978] silver  
  • IEAOrtholog Compara
RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcriptiondefinition[GO:0001077] silver  
  • IEAOrtholog Compara
GO biological process 
Alpha-beta T cell differentiationdefinition[GO:0046632] silver  
  • IEAOrtholog Compara
Epithelial cell morphogenesisdefinition[GO:0003382] silver  
  • IEAOrtholog Compara
Keratinocyte developmentdefinition[GO:0003334] silver  
  • IEAOrtholog Compara
Negative regulation of apoptotic processdefinition[GO:0043066] silver  
  • IEAOrtholog Compara
Negative regulation of cell proliferationdefinition[GO:0008285] silver  
  • IEAOrtholog Compara
Odontogenesis of dentin-containing toothdefinition[GO:0042475] silver  
  • IEAOrtholog Compara
Olfactory bulb axon guidancedefinition[GO:0071678] silver  
  • IEAOrtholog Compara
Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944]  
1
  • IMPMGI
Positive T cell selectiondefinition[GO:0043368] silver  
  • IEAOrtholog Compara
Post-embryonic camera-type eye developmentdefinition[GO:0031077] silver  
  • IEAOrtholog Compara
Regulation of keratinocyte proliferationdefinition[GO:0010837] silver  
  • IEAOrtholog Compara
Regulation of lipid metabolic processdefinition[GO:0019216] silver  
  • IEAOrtholog Compara
Regulation of neuron differentiationdefinition[GO:0045664] silver  
  • IEAOrtholog Compara
Striatal medium spiny neuron differentiationdefinition[GO:0021773] silver  
  • IEAOrtholog Compara
T cell differentiation in thymusdefinition[GO:0033077] silver  
  • IEAOrtholog Compara
T cell receptor V(D)J recombinationdefinition[GO:0033153] silver  
  • IEAOrtholog Compara
Thymus developmentdefinition[GO:0048538] silver  
  • IEAOrtholog Compara
 

Keywords

Biological process 
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Molecular function 
Repressor  definition   [KW-0678]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: BCL11B
GenomeRNAi: 64919
PRO: PR:Q9C0K0