STRADB - STE20-related kinase adapter protein beta - human protein (Function)
 
Home Recent activites arrow-down favorite My favorites arrow-down favorite My labels arrow-down Downloads
Back to ...  
Publication View
Protein
Gene
References

 
STRADB »  STE20-related kinase adapter protein beta  (STRAD beta)
 
Protein also known as:  Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 2 protein.
Gene name:  STRADB
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 22 3
GENE REF ISO

Function

 show evidences
Overview 
Pseudokinase which, in complex with CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta), binds to and activates STK11/LKB1. Adopts a closed conformation typical of active protein kinases and binds STK11/LKB1 as a pseudosubstrate, promoting conformational change of STK11/LKB1 in an active conformation (By similarity).  
1
  • CuratedUniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524]  
  • IEAUniProtKB KW
Protein bindingdefinition[GO:0005515]  
3
  • IPIIntAct
Not  Protein kinase activitydefinition[GO:0004672]  
1
  • IDAUniProtKB
Not  Receptor signaling protein serine/threonine kinase activitydefinition[GO:0004702] silver  
  • IBARefGenome
GO biological process 
Activation of protein kinase activitydefinition[GO:0032147]  
1
  • IDAUniProtKB
Cell morphogenesisdefinition[GO:0000902] silver  
  • IEAOrtholog Compara
JNK cascadedefinition[GO:0007254] silver  
  • IEAOrtholog Compara
Negative regulation of extrinsic apoptotic signaling pathway in absence of liganddefinition[GO:2001240] silver  
  • IEAOrtholog Compara
Protein export from nucleusdefinition[GO:0006611]  
1
  • IDAUniProtKB
Not  Protein phosphorylationdefinition[GO:0006468]  
1
  • IDAUniProtKB
Pathways 
According to Reactome, this protein belongs to the following pathway:
Signal Transduction  REACT_111102  
Caution 
Ser-184 is present instead of the conserved Asp which is expected to be an active site residue.  
  • CuratedUniProtKB
 

Keywords

Biological process 
Cell cycle  definition   [KW-0131]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: ALS2CR2
GenomeRNAi: 55437
PRO: PR:Q9C0K7