SENP6 - Sentrin-specific protease 6 - human protein (Function)
 
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SENP6 »  Sentrin-specific protease 6   [ EC 3.4.22.68 ]
 
Protein also known as:  Sentrin/SUMO-specific protease SENP6.
Gene name:  SENP6
Family name: Peptidase C48
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Protease that deconjugates SUMO1, SUMO2 and SUMO3 from targeted proteins. Processes preferentially poly-SUMO2 and poly-SUMO3 chains, but does not efficiently process SUMO1, SUMO2 and SUMO3 precursors. Deconjugates SUMO1 from RXRA, leading to transcriptional activation. Involved in chromosome alignment and spindle assembly, by regulating the kinetochore CENPH-CENPI-CENPK complex. Desumoylates PML and CENPI, protecting them from degradation by the ubiquitin ligase RNF4, which targets polysumoylated proteins for proteasomal degradation. Desumoylates also RPA1, thus preventing recruitment of RAD51 to the DNA damage foci to initiate DNA repair through homologous recombination.  
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  • UniProtKB
GO molecular function 
Protein bindingdefinition[GO:0005515]  
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  • UniProtKB
SUMO-specific protease activitydefinition[GO:0016929]  
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  • UniProtKB
GO biological process 
Protein desumoylationdefinition[GO:0016926]  
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  • UniProtKB
Protein modification by small protein removaldefinition[GO:0070646]  
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  • UniProtKB
Protein sumoylationdefinition[GO:0016925]  
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  • UniPathway
Proteolysisdefinition[GO:0006508]  
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  • UniProtKB KW
Regulation of kinetochore assemblydefinition[GO:0090234]  
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  • UniProtKB
Regulation of spindle assemblydefinition[GO:0090169]  
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  • UniProtKB
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 3.4.22.68: Hydrolysis of the alpha-linked peptide bond in the sequence Gly-Gly-|-Ala-Thr-Tyr at the C-terminal end of the small ubiquitin-like modifier (SUMO) propeptide, Smt3, leading to the mature form of the protein. A second reaction involves the cleavage of an epsilon-linked peptide bond between the C-terminal glycine of the mature SUMO and the lysine epsilon-amino group of the target protein.  
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  • UniProtKB
 
More information is available from:
Pathways 
This protein is involved in the following pathway
Protein modification; protein sumoylation  
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  • UniProtKB
 

Keywords

Biological process 
Ubl conjugation pathway  definition   [KW-0833]
Molecular function 
Hydrolase  definition   [KW-0378]
Protease  definition   [KW-0645]
Thiol protease  definition   [KW-0788]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: SENP6
GenomeRNAi: 26054
PRO: PR:Q9GZR1