MCOLN1 - Mucolipin-1 - human protein (Function)
 
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Protein
Gene
References

 
MCOLN1 »  Mucolipin-1
 
Gene name:  MCOLN1
Entry whose protein(s) existence is based on evidence at protein level
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1 69 1
GENE REF ISO

Function

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Overview 
Cation channel probably playing a role in the endocytic pathway and in the control of membrane trafficking of proteins and lipids. Could play a major role in Ca(2+) transport regulating lysosomal exocytosis.  
3
  • CuratedUniProtKB
According to TCDB this is a transporter from family:
the polycystin cation channel (pcc) family  1.A.5.3.1  
GO molecular function 
Cation channel activitydefinition[GO:0005261]  
1
  • NASUniProtKB
NAADP-sensitive calcium-release channel activitydefinition[GO:0072345] silver  
  • IEAOrtholog Compara
GO biological process 
Cation transportdefinition[GO:0006812]  
1
  • NASUniProtKB
Release of sequestered calcium ion into cytosoldefinition[GO:0051209] silver  
  • IEAOrtholog Compara
Enzymatic activity 
It is regulated in the following manner
Channel function is transiently modulated by changes in Ca(2+), and inhibited by a reduction of pH; pH changes modify the aggregation state of unitary channels.  
  • CuratedUniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathway:
Lysosome  hsa04142+57192  
According to Reactome, this protein belongs to the following pathways:
Transferrin endocytosis and recycling  REACT_25283  
TRP channels  REACT_169333  
 

Keywords

Biological process 
Calcium transport  definition   [KW-0109]
Ion transport  definition   [KW-0406]
Transport  definition   [KW-0813]
Molecular function 
Ion channel  definition   [KW-0407]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: MCOLN1
GenomeRNAi: 57192
PRO: PR:Q9GZU1
Chemistry
GuidetoPHARMACOLOGY: 501