AICDA - Single-stranded DNA cytosine deaminase - human protein (Function)
 
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Protein
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References

 
AICDA »  Single-stranded DNA cytosine deaminase   [ EC 3.5.4.38 ]
 
Protein also known as:  Activation-induced cytidine deaminase.
Gene name:  AICDA
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 168 2
GENE REF ISO

Function

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Overview 
Single-stranded DNA-specific cytidine deaminase. Involved in somatic hypermutation, gene conversion, and class-switch recombination in B-lymphocytes. Required for several crucial steps of B-cell terminal differentiation necessary for efficient antibody responses. May also play a role in the epigenetic regulation of gene expression by participating in DNA demethylation.  
4
  • CuratedUniProtKB
GO molecular function 
Cytidine deaminase activitydefinition[GO:0004126]  
2
  • IDAUniProtKB
Protein bindingdefinition[GO:0005515]  
5
  • IPIIntAct
  • IPIUniProtKB
Zinc ion bindingdefinition[GO:0008270] silver  
  • IEAInterPro 2 GO
GO biological process 
B cell differentiationdefinition[GO:0030183]  
1
  • NASUniProtKB
Cellular response to lipopolysaccharidedefinition[GO:0071222] silver  
  • IEAOrtholog Compara
DNA demethylationdefinition[GO:0080111]  
1
  • IDAUniProtKB
Isotype switchingdefinition[GO:0045190] silver  
  • IEAOrtholog Compara
mRNA processingdefinition[GO:0006397]  
  • IEAUniProtKB KW
Negative regulation of methylation-dependent chromatin silencingdefinition[GO:0090310]  
1
  • IDAUniProtKB
Somatic diversification of immunoglobulinsdefinition[GO:0016445]  
1
  • IDAUniProtKB
Somatic hypermutation of immunoglobulin genesdefinition[GO:0016446]  
1
  • IMPUniProtKB
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 3.5.4.38: Cytosine in single-stranded DNA + H(2)O uracil in single-stranded DNA + NH(3).  
  • CuratedUniProtKB
It requires the following cofactor
Zinc (By similarity).  
  • CuratedUniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathways:
Intestinal immune network for IgA production  hsa04672+57379  
Primary immunodeficiency  hsa05340+57379  
 

Keywords

Biological process 
mRNA processing  definition   [KW-0507]
Molecular function 
Hydrolase  definition   [KW-0378]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: AICDA
GenomeRNAi: 57379
PRO: PR:Q9GZX7