TWSG1 - Twisted gastrulation protein homolog 1 - human protein (Function)
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TWSG1 »  Twisted gastrulation protein homolog 1
Gene name:  TWSG1
Entry whose protein(s) existence is based on evidence at protein level
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May be involved in dorsoventral axis formation. Seems to antagonize BMP signaling by forming ternary complexes with CHRD and BMPs, thereby preventing BMPs from binding to their receptors. In addition to the anti-BMP function, also has pro-BMP activity, partly mediated by cleavage and degradation of CHRD, which releases BMPs from ternary complexes. May be an important modulator of BMP-regulated cartilage development and chondrocyte differentiation. May play a role in thymocyte development (By similarity).  
  • CuratedUniProtKB
GO biological process 
BMP signaling pathwaydefinition[GO:0030509] silver  
  • IEAOrtholog Compara
Camera-type eye developmentdefinition[GO:0043010] silver  
  • IEAOrtholog Compara
Cell differentiationdefinition[GO:0030154] silver  
  • IEAOrtholog Compara
Forebrain developmentdefinition[GO:0030900] silver  
  • IEAOrtholog Compara
Hemopoiesisdefinition[GO:0030097] silver  
  • IEAOrtholog Compara
Mesoderm formationdefinition[GO:0001707] silver  
  • IEAOrtholog Compara
Negative regulation of BMP signaling pathwaydefinition[GO:0030514] silver  
  • IEAOrtholog Compara
Negative regulation of osteoblast differentiationdefinition[GO:0045668] silver  
  • IEAOrtholog Compara
Ossificationdefinition[GO:0001503] silver  
  • IEAOrtholog Compara
Positive regulation of BMP signaling pathwaydefinition[GO:0030513] silver  
  • IEAOrtholog Compara
Salivary gland morphogenesisdefinition[GO:0007435] silver  
  • IEAOrtholog Compara


Molecular function 
Developmental protein  definition   [KW-0217]
Technical term 
Reference proteome  definition   [KW-1185]

Further external links

GeneWiki: TWSG1
GenomeRNAi: 57045