TWSG1 - Twisted gastrulation protein homolog 1 - human protein (Function)
 
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Protein
Gene
References

 
TWSG1 »  Twisted gastrulation protein homolog 1
 
Gene name:  TWSG1
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
May be involved in dorsoventral axis formation. Seems to antagonize BMP signaling by forming ternary complexes with CHRD and BMPs, thereby preventing BMPs from binding to their receptors. In addition to the anti-BMP function, also has pro-BMP activity, partly mediated by cleavage and degradation of CHRD, which releases BMPs from ternary complexes. May be an important modulator of BMP-regulated cartilage development and chondrocyte differentiation. May play a role in thymocyte development (By similarity).  
1
  • UniProtKB
GO molecular function 
Protein bindingdefinition[GO:0005515]  
1
  • IntAct
GO biological process 
BMP signaling pathwaydefinition[GO:0030509] silver  
1
  • Ortholog Compara
Camera-type eye developmentdefinition[GO:0043010] silver  
1
  • Ortholog Compara
Cell differentiationdefinition[GO:0030154] silver  
1
  • Ortholog Compara
Forebrain developmentdefinition[GO:0030900] silver  
1
  • Ortholog Compara
Hemopoiesisdefinition[GO:0030097] silver  
1
  • Ortholog Compara
Mesoderm formationdefinition[GO:0001707] silver  
1
  • Ortholog Compara
Negative regulation of BMP signaling pathwaydefinition[GO:0030514] silver  
1
  • Ortholog Compara
Negative regulation of osteoblast differentiationdefinition[GO:0045668] silver  
1
  • Ortholog Compara
Ossificationdefinition[GO:0001503] silver  
1
  • Ortholog Compara
Positive regulation of BMP signaling pathwaydefinition[GO:0030513] silver  
1
  • Ortholog Compara
Salivary gland morphogenesisdefinition[GO:0007435] silver  
1
  • Ortholog Compara
 

Keywords

Molecular function 
Developmental protein  definition   [KW-0217]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: TWSG1
GenomeRNAi: 57045
PRO: PR:Q9GZX9