LHPP - Phospholysine phosphohistidine inorganic pyrophosphate phosphatase - human protein (Function)
 
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Protein
Gene
References

 
LHPP »  Phospholysine phosphohistidine inorganic pyrophosphate phosphatase   [ EC 3.6.1.1EC 3.1.3.- ]
 
Gene name:  LHPP
Family name: HAD-like hydrolase
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 12 2
GENE REF ISO

Function

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Overview 
Phosphatase that hydrolyzes imidodiphosphate, 3-phosphohistidine and 6-phospholysine. Has broad substrate specificity and can also hydrolyze inorganic diphosphate, but with lower efficiency (By similarity).  
  • CuratedUniProtKB
GO molecular function 
Inorganic diphosphatase activitydefinition[GO:0004427]  
1
  • IDAUniProtKB
Magnesium ion bindingdefinition[GO:0000287]  
  • ISSOrtholog Curator
Phosphohistidine phosphatase activitydefinition[GO:0008969]  
  • ISSOrtholog Curator
Protein homodimerization activitydefinition[GO:0042803]  
1
  • IPIUniProtKB
GO biological process 
Phosphate-containing compound metabolic processdefinition[GO:0006796]  
1
  • IDAUniProtKB
Protein dephosphorylationdefinition[GO:0006470]  
  • ISSOrtholog Curator
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 3.6.1.1: Diphosphate + H(2)O 2 phosphate.  
1
  • CuratedUniProtKB
It requires the following cofactor
Binds 1 magnesium ion per subunit.  
2
  • CuratedUniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathway:
Oxidative phosphorylation  hsa00190+64077  
 

Biophysicochemical properties

Dependence
pH Optimum pH is 7.0 for PNP, and 5.5 for PPi.

Keywords

Molecular function 
Hydrolase  definition   [KW-0378]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 64077
PRO: PR:Q9H008