ADAM19 - Disintegrin and metalloproteinase domain-containing protein 19 - human protein (Function)
 
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ADAM19 »  Disintegrin and metalloproteinase domain-containing protein 19   [ EC 3.4.24.- ]  (ADAM 19)
 
Protein also known as:  Metalloprotease and disintegrin dendritic antigen marker (MADDAM).
Gene name:  ADAM19
Entry whose protein(s) existence is based on evidence at protein level
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1 27 2
GENE REF ISO

Function

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Overview 
Participates in the proteolytic processing of beta-type neuregulin isoforms which are involved in neurogenesis and synaptogenesis, suggesting a regulatory role in glial cell. Also cleaves alpha-2 macroglobulin. May be involved in osteoblast differentiation and/or osteoblast activity in bone (By similarity).  
  • CuratedUniProtKB
GO molecular function 
Metalloendopeptidase activitydefinition[GO:0004222] silver  
  • IEAInterPro 2 GO
SH3 domain bindingdefinition[GO:0017124]  
  • IEAUniProtKB KW
Zinc ion bindingdefinition[GO:0008270] silver  
  • IEAInterPro 2 GO
GO biological process 
Heart developmentdefinition[GO:0007507] silver  
  • IEAOrtholog Compara
Membrane protein ectodomain proteolysisdefinition[GO:0006509] silver  
  • IEAOrtholog Compara
Enzymatic activity 
It requires the following cofactor
Binds 1 zinc ion per subunit (By similarity).  
  • CuratedUniProtKB
 
More information is available from:
 

Keywords

Molecular function 
Hydrolase  definition   [KW-0378]
Metalloprotease  definition   [KW-0482]
Protease  definition   [KW-0645]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Enzyme and pathway databases
SABIO-RK: Q9H013
Other
GeneWiki: ADAM19
GenomeRNAi: 8728
PRO: PR:Q9H013