NUAK2 - NUAK family SNF1-like kinase 2 - human protein (Function)
 
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NUAK2 »  NUAK family SNF1-like kinase 2   [ EC 2.7.11.1 ]
 
Protein also known as:  SNF1/AMP kinase-related kinase (SNARK).
Gene name:  NUAK2
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Stress-activated kinase involved in tolerance to glucose starvation. Induces cell-cell detachment by increasing F-actin conversion to G-actin. Expression is induced by CD95 or TNF-alpha, via NF-kappa-B. Protects cells from CD95-mediated apoptosis and is required for the increased motility and invasiveness of CD95-activated tumor cells. Able to phosphorylate 'Ser-464' of LATS1.  
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GO molecular function 
ATP bindingdefinition[GO:0005524]  
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  • IDAUniProtKB
Magnesium ion bindingdefinition[GO:0000287]  
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  • IDAUniProtKB
Protein bindingdefinition[GO:0005515]  
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  • IPIUniProtKB
Protein serine/threonine kinase activitydefinition[GO:0004674]  
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  • IDAUniProtKB
GO biological process 
Actin cytoskeleton organizationdefinition[GO:0030036]  
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  • IDAUniProtKB
Apoptotic processdefinition[GO:0006915]  
  • IEAUniProtKB KW
Cellular response to glucose starvationdefinition[GO:0042149]  
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  • IDAUniProtKB
Negative regulation of apoptotic processdefinition[GO:0043066]  
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  • IDAUniProtKB
Protein phosphorylationdefinition[GO:0006468]  
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  • IDAUniProtKB
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.7.11.1: ATP + a protein ADP + a phosphoprotein.  
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  • CuratedUniProtKB
It requires the following cofactor
Magnesium.  
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  • CuratedUniProtKB
It is regulated in the following manner
Activated by phosphorylation on Thr-208.  
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  • CuratedUniProtKB
 

Keywords

Biological process 
Apoptosis  definition   [KW-0053]
Molecular function 
Kinase  definition   [KW-0418]
Serine/threonine-protein kinase  definition   [KW-0723]
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: NUAK2
GenomeRNAi: 81788
PRO: PR:Q9H093
Chemistry
GuidetoPHARMACOLOGY: 2130