PCBD2 - Pterin-4-alpha-carbinolamine dehydratase 2 - human protein (Function)
 
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PCBD2 »  Pterin-4-alpha-carbinolamine dehydratase 2   [ EC 4.2.1.96 ]  (PHS 2)
 
Protein also known as:  Dimerization cofactor of hepatocyte nuclear factor 1 from muscle.
Gene name:  PCBD2
Entry whose protein(s) existence is based on evidence at protein level
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1 6 1
GENE REF ISO

Function

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Overview 
Involved in tetrahydrobiopterin biosynthesis. Seems to both prevent the formation of 7-pterins and accelerate the formation of quinonoid-BH2 (By similarity).  
1
  • CuratedUniProtKB
Regulates the dimerization of homeodomain protein HNF-1-alpha and enhances its transcriptional activity.  
1
  • CuratedUniProtKB
GO molecular function 
4-alpha-hydroxytetrahydrobiopterin dehydratase activitydefinition[GO:0008124]  
  • IEAEC 2 GO
Phenylalanine 4-monooxygenase activitydefinition[GO:0004505] silver  
  • IEAOrtholog Compara
Protein bindingdefinition[GO:0005515]  
1
  • IPIIntAct
GO biological process 
Oxidation-reduction processdefinition[GO:0055114]  
  • IEAOrtholog Compara
Positive regulation of transcription, DNA-templateddefinition[GO:0045893]  
1
  • IDAUniProtKB
Protein heterooligomerizationdefinition[GO:0051291] silver  
  • IEAOrtholog Compara
Protein homotetramerizationdefinition[GO:0051289] silver  
  • IEAOrtholog Compara
Tetrahydrobiopterin biosynthetic processdefinition[GO:0006729]  
  • IEAUniProtKB KW
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 4.2.1.96: (6R)-6-(L-erythro-1,2-dihydroxypropyl)-5,6,7,8-tetrahydro-4a-hydroxypterin (6R)-6-(L-erythro-1,2-dihydroxypropyl)-7,8-dihydro-6H-pterin + H(2)O.  
  • CuratedUniProtKB
Pathways 
 
More information is available from:
 

Keywords

Biological process 
Tetrahydrobiopterin biosynthesis  definition   [KW-0783]
Molecular function 
Lyase  definition   [KW-0456]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: PCBD2
GenomeRNAi: 84105
PRO: PR:Q9H0N5