BCL11A - B-cell lymphoma/leukemia 11A - human protein (Function)
 
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Protein
Gene
References

 
BCL11A »  B-cell lymphoma/leukemia 11A  (BCL-11A)
 
Protein also known as:  Ecotropic viral integration site 9 protein homolog (EVI-9).
Gene name:  BCL11A
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 43 6
GENE REF ISO

Function

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Overview 
Functions as a myeloid and B-cell proto-oncogene. May play important roles in leukemogenesis and hematopoiesis. An essential factor in lymphopoiesis, is required for B-cell formation in fetal liver. May function as a modulator of the transcriptional repression activity of ARP1 (By similarity).  
  • CuratedUniProtKB
GO molecular function 
Metal ion bindingdefinition[GO:0046872]  
  • IEAUniProtKB KW
Isoforms  Iso 2 and Iso 3   Protein heterodimerization activitydefinition[GO:0046982]  
1
  • IPIBHF-UCL
Isoform  Iso 2   Protein homodimerization activitydefinition[GO:0042803]  
1
  • TASBHF-UCL
RNA polymerase II core promoter proximal region sequence-specific DNA bindingdefinition[GO:0000978]  
1
  • IDANTNU_SB
RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcriptiondefinition[GO:0001078]  
1
  • IDANTNU_SB
Transcription corepressor activitydefinition[GO:0003714] silver  
  • IEAOrtholog Compara
GO biological process 
B cell differentiationdefinition[GO:0030183] silver  
  • IEAOrtholog Compara
Isoform  Iso 2   Negative regulation of axon extensiondefinition[GO:0030517]  
1
  • ISSBHF-UCL
Isoform  Iso 2   Negative regulation of collateral sproutingdefinition[GO:0048671]  
1
  • IMPBHF-UCL
Isoform  Iso 2   Negative regulation of dendrite developmentdefinition[GO:2000171]  
1
  • IMPBHF-UCL
Isoform  Iso 2   Negative regulation of neuron projection developmentdefinition[GO:0010977]  
1
  • IDABHF-UCL
Isoform  Iso 3   Negative regulation of protein homooligomerizationdefinition[GO:0032463]  
1
  • ICBHF-UCL
Negative regulation of transcription from RNA polymerase II promoterdefinition[GO:0000122]  
1
  • IDANTNU_SB
Isoform  Iso 3   Positive regulation of collateral sproutingdefinition[GO:0048672]  
1
  • IMPBHF-UCL
Isoform  Iso 3   Positive regulation of neuron projection developmentdefinition[GO:0010976]  
1
  • IDABHF-UCL
Isoform  Iso 2   Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944]  
1
  • ISSBHF-UCL
Protein sumoylationdefinition[GO:0016925]  
  • ISSOrtholog Curator
Isoform  Iso 3   Regulation of dendrite developmentdefinition[GO:0050773]  
1
  • IMPBHF-UCL
T cell differentiationdefinition[GO:0030217] silver  
  • IEAOrtholog Compara
Transcription, DNA-templateddefinition[GO:0006351]  
  • IEAUniProtKB KW
 

Keywords

Biological process 
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Molecular function 
Repressor  definition   [KW-0678]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: BCL11A
GenomeRNAi: 53335
PRO: PR:Q9H165