TRPV6 - Transient receptor potential cation channel subfamily V member 6 - human protein (Function)
 
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TRPV6 »  Transient receptor potential cation channel subfamily V member 6  (TrpV6)
 
Protein also known as:  Epithelial calcium channel 2 (ECaC2).
Gene name:  TRPV6
Entry whose protein(s) existence is based on evidence at protein level
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1 36 2
GENE REF ISO

Function

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Overview 
Calcium selective cation channel probably involved in Ca(2+) uptake in various tissues, including Ca(2+) reabsorption in intestine. The channel is activated by low internal calcium level, probably including intracellular calcium store depletion, and the current exhibits an inward rectification. Inactivation includes both, a rapid Ca(2+)-dependent and a slower Ca(2+)-calmodulin-dependent mechanism, the latter may be regulated by phosphorylation. In vitro, is slowly inhibited by Mg(2+) in a voltage-independent manner. Heteromeric assembly with TRPV5 seems to modify channel properties. TRPV5-TRPV6 heteromultimeric concatemers exhibit voltage-dependent gating (By similarity).  
4
  • CuratedUniProtKB
According to TCDB this is a transporter from family:
the transient receptor potential ca(2+) channel (trp-cc) family  1.A.4.2.11  
GO molecular function 
Calcium channel activitydefinition[GO:0005262]  
1
  • IDAUniProtKB
Calmodulin bindingdefinition[GO:0005516]  
1
  • IDAUniProtKB
Protein bindingdefinition[GO:0005515]  
2
  • IPIIntAct
GO biological process 
Calcium ion transportdefinition[GO:0006816]  
1
  • NASUniProtKB
Regulation of calcium ion-dependent exocytosisdefinition[GO:0017158]  
1
  • NASUniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathways:
Mineral absorption  hsa04978+55503  
Salivary secretion  hsa04970+55503  
According to Reactome, this protein belongs to the following pathway:
TRP channels  REACT_169333  
 

Keywords

Biological process 
Calcium transport  definition   [KW-0109]
Ion transport  definition   [KW-0406]
Transport  definition   [KW-0813]
Molecular function 
Calcium channel  definition   [KW-0107]
Ion channel  definition   [KW-0407]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: TRPV6
GenomeRNAi: 55503
PRO: PR:Q9H1D0
Chemistry
GuidetoPHARMACOLOGY: 512