MYLK2 - Myosin light chain kinase 2, skeletal/cardiac muscle - human protein (Function)
 
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MYLK2 »  Myosin light chain kinase 2, skeletal/cardiac muscle   [ EC 2.7.11.18 ]  (MLCK2)
 
Gene name:  MYLK2
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Implicated in the level of global muscle contraction and cardiac function. Phosphorylates a specific serine in the N-terminus of a myosin light chain.  
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  • CuratedUniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524]  
  • IEAUniProtKB KW
Calmodulin bindingdefinition[GO:0005516]  
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  • ICBHF-UCL
  • ISSOrtholog Curator
Calmodulin-dependent protein kinase activitydefinition[GO:0004683]  
  • ISSOrtholog Curator
Myosin light chain kinase activitydefinition[GO:0004687]  
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  • IDABHF-UCL
  • ISSOrtholog Curator
Protein bindingdefinition[GO:0005515]  
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  • IPIIntAct
GO biological process 
Cardiac muscle contractiondefinition[GO:0060048]  
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  • ICBHF-UCL
Cardiac muscle tissue morphogenesisdefinition[GO:0055008]  
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  • IMPBHF-UCL
Neuromuscular synaptic transmissiondefinition[GO:0007274] silver  
  • IEAOrtholog Compara
Peptidyl-threonine phosphorylationdefinition[GO:0018107]  
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  • IDAUniProtKB
Positive regulation of gene expressiondefinition[GO:0010628]  
1
  • IDAUniProtKB
Protein autophosphorylationdefinition[GO:0046777]  
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  • IDAUniProtKB
Regulation of muscle filament slidingdefinition[GO:0032971]  
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  • IDABHF-UCL
Satellite cell differentiationdefinition[GO:0014816] silver  
  • IEAOrtholog Compara
Skeletal muscle cell differentiationdefinition[GO:0035914]  
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  • IDAUniProtKB
Striated muscle contractiondefinition[GO:0006941]  
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  • IDABHF-UCL
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.7.11.18: ATP + [myosin light-chain] ADP + [myosin light-chain] phosphate.  
  • CuratedUniProtKB
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathways:
Calcium signaling pathway  hsa04020+85366  
Focal adhesion  hsa04510+85366  
Gastric acid secretion  hsa04971+85366  
Regulation of actin cytoskeleton  hsa04810+85366  
Vascular smooth muscle contraction  hsa04270+85366  
 

Keywords

Molecular function 
Kinase  definition   [KW-0418]
Serine/threonine-protein kinase  definition   [KW-0723]
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: MYLK2
GenomeRNAi: 85366
PRO: PR:Q9H1R3
Chemistry
GuidetoPHARMACOLOGY: 1553