Combining with incidental electromagnetic radiation, particularly visible light, and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex.
J. Neurosci. 19, 3681-3690 (1999)[PubMed:10234000]
We have identified a mammalian opsin, encephalopsin, that shows strong and specific expression in the brain. Encephalopsin defines a new family of opsins and shows highest homology to vertebrate retinal and pineal opsins. Encephalopsin is highly expressed in the preoptic area and paraventricular nucleus of the hypothalamus, both regions implicated in encephalic photoreception in nonmammalian vertebrates. In addition, encephalopsin shows highly patterned expression in other regions of the brain, being enriched in selected regions of the cerebral cortex, cerebellar Purkinje cells, a subset of striatal neurons, selected thalamic nuclei, and a subset of interneurons in the ventral horn of the spinal cord. Rostrocaudal gradients of encephalopsin expression are present in the cortex, cerebellum, and striatum. Radial stripes of encephalopsin expression are seen in the cerebellum. In the cortex and cerebellum, encephalopsin expression is considerably higher and more highly patterned in the adult than in the neonate. Encephalopsin is the first putative extraocular opsin identified in mammals and may play a role in encephalic photoreception.
Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex.
J. Neurosci. 19, 3681-3690 (1999)[PubMed:10234000]
We have identified a mammalian opsin, encephalopsin, that shows strong and specific expression in the brain. Encephalopsin defines a new family of opsins and shows highest homology to vertebrate retinal and pineal opsins. Encephalopsin is highly expressed in the preoptic area and paraventricular nucleus of the hypothalamus, both regions implicated in encephalic photoreception in nonmammalian vertebrates. In addition, encephalopsin shows highly patterned expression in other regions of the brain, being enriched in selected regions of the cerebral cortex, cerebellar Purkinje cells, a subset of striatal neurons, selected thalamic nuclei, and a subset of interneurons in the ventral horn of the spinal cord. Rostrocaudal gradients of encephalopsin expression are present in the cortex, cerebellum, and striatum. Radial stripes of encephalopsin expression are seen in the cerebellum. In the cortex and cerebellum, encephalopsin expression is considerably higher and more highly patterned in the adult than in the neonate. Encephalopsin is the first putative extraocular opsin identified in mammals and may play a role in encephalic photoreception.
The function of absorbing and responding to incidental electromagnetic radiation, particularly visible light. The response may involve a change in conformation.
J. Neurosci. 19, 3681-3690 (1999)[PubMed:10234000]
We have identified a mammalian opsin, encephalopsin, that shows strong and specific expression in the brain. Encephalopsin defines a new family of opsins and shows highest homology to vertebrate retinal and pineal opsins. Encephalopsin is highly expressed in the preoptic area and paraventricular nucleus of the hypothalamus, both regions implicated in encephalic photoreception in nonmammalian vertebrates. In addition, encephalopsin shows highly patterned expression in other regions of the brain, being enriched in selected regions of the cerebral cortex, cerebellar Purkinje cells, a subset of striatal neurons, selected thalamic nuclei, and a subset of interneurons in the ventral horn of the spinal cord. Rostrocaudal gradients of encephalopsin expression are present in the cortex, cerebellum, and striatum. Radial stripes of encephalopsin expression are seen in the cerebellum. In the cortex and cerebellum, encephalopsin expression is considerably higher and more highly patterned in the adult than in the neonate. Encephalopsin is the first putative extraocular opsin identified in mammals and may play a role in encephalic photoreception.
J. Neurosci. 19, 3681-3690 (1999)[PubMed:10234000]
We have identified a mammalian opsin, encephalopsin, that shows strong and specific expression in the brain. Encephalopsin defines a new family of opsins and shows highest homology to vertebrate retinal and pineal opsins. Encephalopsin is highly expressed in the preoptic area and paraventricular nucleus of the hypothalamus, both regions implicated in encephalic photoreception in nonmammalian vertebrates. In addition, encephalopsin shows highly patterned expression in other regions of the brain, being enriched in selected regions of the cerebral cortex, cerebellar Purkinje cells, a subset of striatal neurons, selected thalamic nuclei, and a subset of interneurons in the ventral horn of the spinal cord. Rostrocaudal gradients of encephalopsin expression are present in the cortex, cerebellum, and striatum. Radial stripes of encephalopsin expression are seen in the cerebellum. In the cortex and cerebellum, encephalopsin expression is considerably higher and more highly patterned in the adult than in the neonate. Encephalopsin is the first putative extraocular opsin identified in mammals and may play a role in encephalic photoreception.
The series of events in which a visible light stimulus is received by a cell and converted into a molecular signal. A visible light stimulus is electromagnetic radiation that can be perceived visually by an organism; for organisms lacking a visual system, this can be defined as light with a wavelength within the range 380 to 780 nm.
J. Neurosci. 19, 3681-3690 (1999)[PubMed:10234000]
We have identified a mammalian opsin, encephalopsin, that shows strong and specific expression in the brain. Encephalopsin defines a new family of opsins and shows highest homology to vertebrate retinal and pineal opsins. Encephalopsin is highly expressed in the preoptic area and paraventricular nucleus of the hypothalamus, both regions implicated in encephalic photoreception in nonmammalian vertebrates. In addition, encephalopsin shows highly patterned expression in other regions of the brain, being enriched in selected regions of the cerebral cortex, cerebellar Purkinje cells, a subset of striatal neurons, selected thalamic nuclei, and a subset of interneurons in the ventral horn of the spinal cord. Rostrocaudal gradients of encephalopsin expression are present in the cortex, cerebellum, and striatum. Radial stripes of encephalopsin expression are seen in the cerebellum. In the cortex and cerebellum, encephalopsin expression is considerably higher and more highly patterned in the adult than in the neonate. Encephalopsin is the first putative extraocular opsin identified in mammals and may play a role in encephalic photoreception.
A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription.
J. Neurosci. 19, 3681-3690 (1999)[PubMed:10234000]
We have identified a mammalian opsin, encephalopsin, that shows strong and specific expression in the brain. Encephalopsin defines a new family of opsins and shows highest homology to vertebrate retinal and pineal opsins. Encephalopsin is highly expressed in the preoptic area and paraventricular nucleus of the hypothalamus, both regions implicated in encephalic photoreception in nonmammalian vertebrates. In addition, encephalopsin shows highly patterned expression in other regions of the brain, being enriched in selected regions of the cerebral cortex, cerebellar Purkinje cells, a subset of striatal neurons, selected thalamic nuclei, and a subset of interneurons in the ventral horn of the spinal cord. Rostrocaudal gradients of encephalopsin expression are present in the cortex, cerebellum, and striatum. Radial stripes of encephalopsin expression are seen in the cerebellum. In the cortex and cerebellum, encephalopsin expression is considerably higher and more highly patterned in the adult than in the neonate. Encephalopsin is the first putative extraocular opsin identified in mammals and may play a role in encephalic photoreception.
J. Neurosci. 19, 3681-3690 (1999)[PubMed:10234000]
We have identified a mammalian opsin, encephalopsin, that shows strong and specific expression in the brain. Encephalopsin defines a new family of opsins and shows highest homology to vertebrate retinal and pineal opsins. Encephalopsin is highly expressed in the preoptic area and paraventricular nucleus of the hypothalamus, both regions implicated in encephalic photoreception in nonmammalian vertebrates. In addition, encephalopsin shows highly patterned expression in other regions of the brain, being enriched in selected regions of the cerebral cortex, cerebellar Purkinje cells, a subset of striatal neurons, selected thalamic nuclei, and a subset of interneurons in the ventral horn of the spinal cord. Rostrocaudal gradients of encephalopsin expression are present in the cortex, cerebellum, and striatum. Radial stripes of encephalopsin expression are seen in the cerebellum. In the cortex and cerebellum, encephalopsin expression is considerably higher and more highly patterned in the adult than in the neonate. Encephalopsin is the first putative extraocular opsin identified in mammals and may play a role in encephalic photoreception.
Any process that modulates the frequency, rate or extent of a circadian rhythm. A circadian rhythm is a biological process in an organism that recurs with a regularity of approximately 24 hours.
J. Neurosci. 19, 3681-3690 (1999)[PubMed:10234000]
We have identified a mammalian opsin, encephalopsin, that shows strong and specific expression in the brain. Encephalopsin defines a new family of opsins and shows highest homology to vertebrate retinal and pineal opsins. Encephalopsin is highly expressed in the preoptic area and paraventricular nucleus of the hypothalamus, both regions implicated in encephalic photoreception in nonmammalian vertebrates. In addition, encephalopsin shows highly patterned expression in other regions of the brain, being enriched in selected regions of the cerebral cortex, cerebellar Purkinje cells, a subset of striatal neurons, selected thalamic nuclei, and a subset of interneurons in the ventral horn of the spinal cord. Rostrocaudal gradients of encephalopsin expression are present in the cortex, cerebellum, and striatum. Radial stripes of encephalopsin expression are seen in the cerebellum. In the cortex and cerebellum, encephalopsin expression is considerably higher and more highly patterned in the adult than in the neonate. Encephalopsin is the first putative extraocular opsin identified in mammals and may play a role in encephalic photoreception.
The series of events required for an organism to receive a visual stimulus, convert it to a molecular signal, and recognize and characterize the signal. Visual stimuli are detected in the form of photons and are processed to form an image.
IEAInterPro 2 GO
Pathways
According to Reactome, this protein belongs to the following pathway:
Protein involved in sensory transduction, the process by which a cell converts an extracellular signal, such as light, taste, sound, touch or smell, into electric signals.
Receptors which transduce extracellular signals across the cell membrane. At the external side they receive a ligand (a photon in case of opsins), and at the cytosolic side they activate a guanine nucleotide-binding (G) protein. These receptors are hydrophobic proteins that cross the membrane seven times.
Protein involved in the convertion of light directly into a signal. These proteins are classified in a limited number of families based on the chemical structure of the light-absorbing chromophores involved, and also on protein sequence similarities to discriminate the many photoreceptor proteins that bind a flavin derivative. Accordingly, the most important families are the rhodopsins, the phytochromes, the xanthopsins, the cryptochromes, the phototropins and the BLUF proteins.
Protein found in the retina or, in the case of bacteriorhodopsin, in the purple membrane of halobacteria, and which acts as a photoreceptor and which binds a retinal chromophore.
A reference proteome is a set of protein sequences derived from a complete proteome which constitutes a defined standard for a particular user community. Reference proteomes are manually defined according to a number of criteria. They cover the proteomes of well- studied model organisms and other proteomes of interest for biomedical and biotechnological research. Reference proteomes have been selected to provide broad coverage of the tree of life, and constitute a representative cross-section of the taxonomic diversity to be found within UniProtKB.
My favorites 
My labels 
Login
