ABCG8 - ATP-binding cassette sub-family G member 8 - human protein (Function)
 
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ABCG8 »  ATP-binding cassette sub-family G member 8
 
Protein also known as:  Sterolin-2.
Gene name:  ABCG8
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 68 2
GENE REF ISO

Function

 show evidences
Overview 
Transporter that appears to play an indispensable role in the selective transport of the dietary cholesterol in and out of the enterocytes and in the selective sterol excretion by the liver into bile.  
  • CuratedUniProtKB
According to TCDB this is a transporter from family:
the atp-binding cassette (abc) superfamily  3.A.1.204.5  
GO molecular function 
Contributes to ATP bindingdefinition[GO:0005524]  
1
  • IDABHF-UCL
Contributes to ATPase activitydefinition[GO:0016887]  
1
  • IDABHF-UCL
Contributes to cholesterol transporter activitydefinition[GO:0017127]  
1
  • IGIBHF-UCL
Protein bindingdefinition[GO:0005515]  
1
  • IPIIntAct
Protein heterodimerization activitydefinition[GO:0046982]  
1
  • IPIBHF-UCL
GO biological process 
ATP catabolic processdefinition[GO:0006200]  
1
  • IDAGOC
  • IEAInterPro 2 GO
Cholesterol effluxdefinition[GO:0033344]  
1
  • IGIBHF-UCL
Cholesterol homeostasisdefinition[GO:0042632]  
1
  • IMPBHF-UCL
Excretiondefinition[GO:0007588]  
1
  • IGIBHF-UCL
Intestinal cholesterol absorptiondefinition[GO:0030299]  
1
  • ICBHF-UCL
Negative regulation of intestinal cholesterol absorptiondefinition[GO:0045796]  
1
  • IMPBHF-UCL
Negative regulation of intestinal phytosterol absorptiondefinition[GO:0010949]  
1
  • IMPBHF-UCL
Phospholipid transportdefinition[GO:0015914] silver  
  • IEAOrtholog Compara
Response to drugdefinition[GO:0042493] silver  
  • IEAOrtholog Compara
Response to nutrientdefinition[GO:0007584] silver  
  • IEAOrtholog Compara
Pathways 
According to KEGG, this protein belongs to the following pathways:
ABC transporters  hsa02010+64241  
Bile secretion  hsa04976+64241  
Fat digestion and absorption  hsa04975+64241  
According to Reactome, this protein belongs to the following pathways:
ABCA transporters in lipid homeostasis  REACT_111158  
Trafficking of dietary sterols  REACT_13781  
Caution 
Seems to have a defective ATP-binding region.  
  • CuratedUniProtKB
 

Keywords

Biological process 
Transport  definition   [KW-0813]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: ABCG8
GenomeRNAi: 64241
PRO: PR:Q9H221