S1PR5 - Sphingosine 1-phosphate receptor 5 - human protein (Function)
 
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Protein
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References

 
S1PR5 »  Sphingosine 1-phosphate receptor 5  (S1P5)
 
Protein also known as:  Endothelial differentiation G-protein-coupled receptor 8.
Gene name:  S1PR5
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. Is coupled to both the G(i/0)alpha and G(12) subclass of heteromeric G-proteins (By similarity). May play a regulatory role in the transformation of radial glial cells into astrocytes and may affect proliferative activity of these cells.  
1
  • CuratedUniProtKB
GO molecular function 
Sphingosine-1-phosphate receptor activitydefinition[GO:0038036] silver  
  • IEAInterPro 2 GO
GO biological process 
Regulation of neuron differentiationdefinition[GO:0045664] silver  
  • IEAOrtholog Compara
Pathways 
According to KEGG, this protein belongs to the following pathway:
Neuroactive ligand-receptor interaction  hsa04080+53637  
According to Reactome, this protein belongs to the following pathway:
Signal Transduction  REACT_111102  
 

Keywords

Molecular function 
G-protein coupled receptor  definition   [KW-0297]
Receptor  definition   [KW-0675]
Transducer  definition   [KW-0807]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: S1PR5
GenomeRNAi: 53637
PRO: PR:Q9H228
Chemistry
GuidetoPHARMACOLOGY: 279