PORCN - Protein-serine O-palmitoleoyltransferase porcupine - human protein (Function)
 
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PORCN »  Protein-serine O-palmitoleoyltransferase porcupine   [ EC 2.3.1.- ]
 
Protein also known as:  Protein MG61.
Gene name:  PORCN
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Protein-serine O-palmitoleoyltransferase that acts as a key regulator of the Wnt signaling pathway by mediating the attachment of palmitoleate, a 16-carbon monounsaturated fatty acid (C16:1), to Wnt proteins. Serine palmitoleylation of WNT proteins is required for efficient binding to frizzled receptors.  
5
  • UniProtKB
GO molecular function 
Palmitoleoyltransferase activitydefinition[GO:1990698]  
1
  • Ortholog Curator
GO biological process 
Glycoprotein metabolic processdefinition[GO:0009100] silver  
1
  • Ortholog Compara
Protein lipidationdefinition[GO:0006497]  
1
  • Ortholog Curator
Protein palmitoleylationdefinition[GO:0045234]  
1
  • Ortholog Curator
Wnt signaling pathwaydefinition[GO:0016055]  
1
  • Ortholog Curator
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.3.1.-: (9Z)-hexadecenoyl-CoA + [Wnt]-L-serine CoA + [Wnt]-O-(9Z)-hexadecenoyl-L-serine.  
2
  • UniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathway:
Wnt signaling pathway  hsa04310+64840  
According to Reactome, this protein belongs to the following pathways:
WNT ligand biogenesis and trafficking  REACT_163710  
WNT ligand secretion is abrogated by the PORCN inhibitor LGK974  REACT_263933  
Caution 
Was initially thought to mediate palmitoylation of Wnt proteins (PubMed24292069). It was later shown that it instead acts as a serine O-palmitoleoyltransferase that mediates the attachment of palmitoleate, a 16-carbon monounsaturated fatty acid (C16:1), to Wnt proteins.  
2
  • UniProtKB
 

Keywords

Biological process 
Wnt signaling pathway  definition   [KW-0879]
Molecular function 
Acyltransferase  definition   [KW-0012]
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 64840
PRO: PR:Q9H237