P2RY12 - P2Y purinoceptor 12 - human protein (Function)
 
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P2RY12 »  P2Y purinoceptor 12  (P2Y12)
 
Protein also known as:  P2Y12 platelet ADP receptor (P2Y(ADP)).
Gene name:  P2RY12
Entry whose protein(s) existence is based on evidence at protein level
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1 117 1
GENE REF ISO

Function

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Overview 
Receptor for ADP and ATP coupled to G-proteins that inhibit the adenylyl cyclase second messenger system. Not activated by UDP and UTP. Required for normal platelet aggregation and blood coagulation.  
  • CuratedUniProtKB
GO molecular function 
ADP receptor activitydefinition[GO:0001621]  
2
  • IMPUniProtKB
G-protein coupled adenosine receptor activitydefinition[GO:0001609] silver  
  • IEAOrtholog Compara
GO biological process 
Adenosine receptor signaling pathwaydefinition[GO:0001973] silver  
  • IEAOrtholog Compara
Adenylate cyclase-inhibiting G-protein coupled receptor signaling pathwaydefinition[GO:0007193]  
1
  • IMPUniProtKB
Calcium ion transmembrane transportdefinition[GO:0070588] silver  
  • IEAOrtholog Compara
Cell projection organizationdefinition[GO:0030030] silver  
  • IEAOrtholog Compara
G-protein coupled purinergic nucleotide receptor signaling pathwaydefinition[GO:0035589]  
2
  • IMPGOC
  • IEAOrtholog Compara
  • IEAInterPro 2 GO
G-protein coupled receptor signaling pathwaydefinition[GO:0007186]  
1
  • IDAUniProtKB
Hemostasisdefinition[GO:0007599]  
1
  • NASUniProtKB
Negative regulation of cell differentiationdefinition[GO:0045596] silver  
  • IEAOrtholog Compara
Negative regulation of norepinephrine secretiondefinition[GO:0010700] silver  
  • IEAOrtholog Compara
Platelet aggregationdefinition[GO:0070527]  
1
  • IMPUniProtKB
Positive regulation of ion transportdefinition[GO:0043270] silver  
  • IEAOrtholog Compara
Potassium ion transmembrane transportdefinition[GO:0071805] silver  
  • IEAOrtholog Compara
Protein kinase B signalingdefinition[GO:0043491] silver  
  • IEAOrtholog Compara
Regulation of calcium ion transportdefinition[GO:0051924] silver  
  • IEAOrtholog Compara
Pathways 
According to Reactome, this protein belongs to the following pathways:
ADP signalling through P2Y purinoceptor 12  REACT_20653  
G alpha (i) signalling events  REACT_19231  
P2Y receptors  REACT_18289  
 

Keywords

Biological process 
Blood coagulation  definition   [KW-0094]
Hemostasis  definition   [KW-0356]
Molecular function 
G-protein coupled receptor  definition   [KW-0297]
Receptor  definition   [KW-0675]
Transducer  definition   [KW-0807]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: P2Y12
GenomeRNAi: 64805
PRO: PR:Q9H244
Chemistry
GuidetoPHARMACOLOGY: 328