P2RY12 - P2Y purinoceptor 12 - human protein (Function)
 
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P2RY12 »  P2Y purinoceptor 12  (P2Y12)
 
Protein also known as:  P2Y12 platelet ADP receptor (P2Y(ADP)).
Gene name:  P2RY12
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Receptor for ADP and ATP coupled to G-proteins that inhibit the adenylyl cyclase second messenger system. Not activated by UDP and UTP. Involved in platelet aggregation.  
  • CuratedUniProtKB
GO molecular function 
ADP receptor activitydefinition[GO:0001621] silver  
  • IEAOrtholog Compara
G-protein coupled adenosine receptor activitydefinition[GO:0001609] silver  
  • IEAOrtholog Compara
GO biological process 
Adenylate cyclase-modulating G-protein coupled receptor signaling pathwaydefinition[GO:0007188] silver  
  • IEAOrtholog Compara
Calcium ion transmembrane transportdefinition[GO:0070588] silver  
  • IEAOrtholog Compara
Cell projection organizationdefinition[GO:0030030] silver  
  • IEAOrtholog Compara
Hemostasisdefinition[GO:0007599]  
1
  • NASUniProtKB
Negative regulation of cell differentiationdefinition[GO:0045596] silver  
  • IEAOrtholog Compara
Negative regulation of norepinephrine secretiondefinition[GO:0010700] silver  
  • IEAOrtholog Compara
Platelet aggregationdefinition[GO:0070527] silver  
  • IEAOrtholog Compara
Positive regulation of ion transportdefinition[GO:0043270] silver  
  • IEAOrtholog Compara
Potassium ion transmembrane transportdefinition[GO:0071805] silver  
  • IEAOrtholog Compara
Protein kinase B signalingdefinition[GO:0043491] silver  
  • IEAOrtholog Compara
Regulation of calcium ion transportdefinition[GO:0051924] silver  
  • IEAOrtholog Compara
Pathways 
According to Reactome, this protein belongs to the following pathways:
Hemostasis  REACT_604  
Signal Transduction  REACT_111102  
 

Keywords

Molecular function 
G-protein coupled receptor  definition   [KW-0297]
Receptor  definition   [KW-0675]
Transducer  definition   [KW-0807]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: P2Y12
GenomeRNAi: 64805
PRO: PR:Q9H244
Chemistry
GuidetoPHARMACOLOGY: 328