CDH23 - Cadherin-23 - human protein (Function)
 
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Protein
Gene
References

 
CDH23 »  Cadherin-23
 
Gene name:  CDH23
Entry whose protein(s) existence is based on evidence at protein level
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1 59 11
GENE REF ISO

Function

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Overview 
Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells. CDH23 is required for establishing and/or maintaining the proper organization of the stereocilia bundle of hair cells in the cochlea and the vestibule during late embryonic/early postnatal development. It is part of the functional network formed by USH1C, USH1G, CDH23 and MYO7A that mediates mechanotransduction in cochlear hair cells. Required for normal hearing.  
  • CuratedUniProtKB
GO molecular function 
Calcium ion bindingdefinition[GO:0005509] silver  
  • IEAInterPro 2 GO
Protein bindingdefinition[GO:0005515]  
1
  • IPIHGNC
GO biological process 
Calcium ion transportdefinition[GO:0006816]  
1
  • IMPDFLAT
Calcium-dependent cell-cell adhesiondefinition[GO:0016339]  
1
  • NASUniProtKB
Cytosolic calcium ion homeostasisdefinition[GO:0051480]  
1
  • IMPDFLAT
Equilibrioceptiondefinition[GO:0050957]  
1
  • IMPHGNC
Homophilic cell adhesiondefinition[GO:0007156] silver  
  • IEAInterPro 2 GO
Photoreceptor cell maintenancedefinition[GO:0045494]  
1
  • IMPHGNC
Response to stimulusdefinition[GO:0050896]  
  • IEAUniProtKB KW
Sensory perception of light stimulusdefinition[GO:0050953]  
1
  • IMPHGNC
Sensory perception of sounddefinition[GO:0007605]  
3
  • IMPDFLAT
  • IMPHGNC
  • IMPMGI
Visual perceptiondefinition[GO:0007601]  
  • IEAUniProtKB KW
 

Keywords

Biological process 
Cell adhesion  definition   [KW-0130]
Hearing  definition   [KW-1009]
Sensory transduction  definition   [KW-0716]
Vision  definition   [KW-0844]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: CDH23
GenomeRNAi: 64072
PRO: PR:Q9H251