KCNN2 - Small conductance calcium-activated potassium channel protein 2 - human protein (Function)
 
Home Recent activites arrow-down favorite My favorites arrow-down favorite My labels arrow-down Downloads
Back to ...  
Publication View
Protein
Gene
References

 
KCNN2 »  Small conductance calcium-activated potassium channel protein 2  (SK2)
 
Protein also known as:  KCa2.2.
Gene name:  KCNN2
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 31 2
GENE REF ISO

Function

 show evidences
Overview 
Forms a voltage-independent potassium channel activated by intracellular calcium. Activation is followed by membrane hyperpolarization. Thought to regulate neuronal excitability by contributing to the slow component of synaptic afterhyperpolarization. The channel is blocked by apamin.  
  • CuratedUniProtKB
According to TCDB this is a transporter from family:
the voltage-gated ion channel (vic) superfamily  1.A.1.16.1  
GO molecular function 
Alpha-actinin bindingdefinition[GO:0051393]  
1
  • IPIBHF-UCL
Calcium-activated potassium channel activitydefinition[GO:0015269]  
1
  • IDABHF-UCL
Calmodulin bindingdefinition[GO:0005516] silver  
  • IBARefGenome
Protein homodimerization activitydefinition[GO:0042803]  
1
  • IPIBHF-UCL
Small conductance calcium-activated potassium channel activitydefinition[GO:0016286]  
1
  • TASUniProtKB
  • IBARefGenome
GO biological process 
Potassium ion transmembrane transportdefinition[GO:0071805]  
1
  • IDABHF-UCL
Potassium ion transportdefinition[GO:0006813]  
1
  • NASUniProtKB
Regulation of potassium ion transmembrane transportdefinition[GO:1901379]  
1
  • IDABHF-UCL
Pathways 
According to KEGG, this protein belongs to the following pathway:
Bile secretion  hsa04976+3781  
According to Reactome, this protein belongs to the following pathway:
Neuronal System  REACT_13685  
 

Keywords

Biological process 
Ion transport  definition   [KW-0406]
Transport  definition   [KW-0813]
Molecular function 
Ion channel  definition   [KW-0407]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: KCNN2
GenomeRNAi: 3781
PRO: PR:Q9H2S1
Chemistry
GuidetoPHARMACOLOGY: 382