SLC12A5 - Solute carrier family 12 member 5 - human protein (Function)
 
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Protein
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References

 
SLC12A5 »  Solute carrier family 12 member 5
 
Protein also known as:  Electroneutral potassium-chloride cotransporter 2.
Gene name:  SLC12A5
Family name: SLC12A transporter
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 43 2
GENE REF ISO

Function

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Overview 
Mediates electroneutral potassium-chloride cotransport in mature neurons. Transport occurs under isotonic conditions, but is activated 20-fold by cell swelling. Important for Cl(-) homeostasis in neurons.  
  • CuratedUniProtKB
According to TCDB this is a transporter from family:
the cation-chloride cotransporter (ccc) family  2.A.30.5.6  
GO molecular function 
Potassium:chloride symporter activitydefinition[GO:0015379]  
1
  • NASUniProtKB
Isoform  Iso 1   Protein kinase bindingdefinition[GO:0019901]  
1
  • IPIBHF-UCL
GO biological process 
Cellular ion homeostasisdefinition[GO:0006873]  
1
  • NASUniProtKB
Chloride transmembrane transportdefinition[GO:1902476]  
1
  • NASGOC
  • IEAInterPro 2 GO
Learningdefinition[GO:0007612] silver  
  • IEAOrtholog Compara
Multicellular organism growthdefinition[GO:0035264] silver  
  • IEAOrtholog Compara
Potassium ion transportdefinition[GO:0006813]  
  • IEAUniProtKB KW
Response to drugdefinition[GO:0042493] silver  
  • IEAOrtholog Compara
Synaptic transmissiondefinition[GO:0007268] silver  
  • IEAOrtholog Compara
Thermosensory behaviordefinition[GO:0040040] silver  
  • IEAOrtholog Compara
Transportdefinition[GO:0006810]  
1
  • NASUniProtKB
Enzymatic activity 
It is regulated in the following manner
Inhibited by WNK3.  
1
  • CuratedUniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathway:
GABAergic synapse  hsa04727+57468  
According to Reactome, this protein belongs to the following pathway:
Cation-coupled Chloride cotransporters  REACT_19315  
Note 
Inhibited by furosemide and bumetanide.  
  • CuratedUniProtKB
 

Keywords

Biological process 
Ion transport  definition   [KW-0406]
Potassium transport  definition   [KW-0633]
Symport  definition   [KW-0769]
Transport  definition   [KW-0813]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: Chloride_potassium_symporter_5
GenomeRNAi: 57468
PRO: PR:Q9H2X9
Chemistry
GuidetoPHARMACOLOGY: 972