PNN - Pinin - human protein (Function)
 
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PNN »  Pinin
 
Protein also known as:  140 kDa nuclear and cell adhesion-related phosphoprotein.
Gene name:  PNN
Family name: Pinin
Entry whose protein(s) existence is based on evidence at protein level
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1 55 2
GENE REF ISO

Function

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Overview 
Transcriptional activator binding to the E-box 1 core sequence of the E-cadherin promoter gene; the core-binding sequence is 5'CAGGTG-3'. Capable of reversing CTBP1-mediated transcription repression. Auxiliary component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Participates in the regulation of alternative pre-mRNA splicing. Associates to spliced mRNA within 60 nt upstream of the 5'-splice sites. Component of the PSAP complex which binds RNA in a sequence-independent manner and is proposed to be recruited to the EJC prior to or during the splicing process and to regulate specific excision of introns in specific transcription subsets. Involved in the establishment and maintenance of epithelia cell-cell adhesion. Potential tumor suppressor for renal cell carcinoma.  
7
  • CuratedUniProtKB
According to TCDB this is a transporter from family:
the nuclear mrna exporter (mrna-e) family  3.A.18.1.1  
GO molecular function 
DNA bindingdefinition[GO:0003677]  
  • IEAUniProtKB KW
Structural molecule activitydefinition[GO:0005198]  
1
  • NASPINC
GO biological process 
Cell adhesiondefinition[GO:0007155]  
1
  • TASPINC
mRNA splicing, via spliceosomedefinition[GO:0000398]  
1
  • ICUniProtKB
Regulation of transcription, DNA-templateddefinition[GO:0006355]  
  • IEAUniProtKB KW
Transcription, DNA-templateddefinition[GO:0006351]  
  • IEAUniProtKB KW
Pathways 
According to KEGG, this protein belongs to the following pathways:
mRNA surveillance pathway  hsa03015+5411  
RNA transport  hsa03013+5411  
 

Keywords

Biological process 
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
mRNA processing  definition   [KW-0507]
mRNA splicing  definition   [KW-0508]
Molecular function 
Activator  definition   [KW-0010]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: Pinin
GenomeRNAi: 5411
PRO: PR:Q9H307